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. 1984 Dec;58(3):619–624.

Thymoma and hypogammaglobulinaemia with and without T suppressor cells.

M K Brenner, J G Reittie, H R Chadda, A Pollock, G L Asherson
PMCID: PMC1577101  PMID: 6239720

Abstract

Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cells. It has been suggested that these T cells are responsible for the observed hypogammaglobulinaemia. We report a patient with thymoma and hypogammaglobulinaemia who lacks these distinctive suppressor cells and has normal B cell numbers. It is therefore incorrect to propose a single pathogenic mechanism for hypogammaglobulinaemia in association with thymoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson J., Schreier M. H., Melchers F. T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612–1616. doi: 10.1073/pnas.77.3.1612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brenner M. K., Newton C. A., North M. E., Weyman C., Farrant J. The interaction of specific T-cell help and non-specific B-cell growth factors in the production of anti-tetanus antibody by human B cells grown in serum-free microcultures. Immunology. 1983 Nov;50(3):377–385. [PMC free article] [PubMed] [Google Scholar]
  3. Callard R. E., Smith C. M., Beverley P. C. Phenotype of human T helper and suppressor cells in an in vitro specific antibody response. Eur J Immunol. 1982 Mar;12(3):232–236. doi: 10.1002/eji.1830120312. [DOI] [PubMed] [Google Scholar]
  4. Iscove N. N., Melchers F. Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes. J Exp Med. 1978 Mar 1;147(3):923–933. doi: 10.1084/jem.147.3.923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Litwin S. D., Zanjani E. D. Lymphocytes suppressing both immunoglobulin production and erythroid differentiation in hypogammaglobulinaemia. Nature. 1977 Mar 3;266(5597):57–58. doi: 10.1038/266057a0. [DOI] [PubMed] [Google Scholar]
  6. Mitchell E. B., Platts-Mills T. A., Pereira R. S., Malkovska V., Webster A. D. Acquired basophil and eosinophil deficiency in a patient with hypogammaglobulinaemia associated with thymoma. Clin Lab Haematol. 1983;5(3):253–257. doi: 10.1111/j.1365-2257.1983.tb01361.x. [DOI] [PubMed] [Google Scholar]
  7. North M. E., Brenner M. K. Induction of immunoglobulin and antigen-dependent antibody synthesis in human lymphocytes, using supernatants from mitogen-stimulated cultures. Immunology. 1983 Jan;48(1):157–163. [PMC free article] [PubMed] [Google Scholar]
  8. Pereira S., Webster D., Platts-Mills T. Immature B cells in fetal development and immunodeficiency: studies of IgM, IgG, IgA and IgD production in vitro using Epstein-Barr virus activation. Eur J Immunol. 1982 Jul;12(7):540–546. doi: 10.1002/eji.1830120703. [DOI] [PubMed] [Google Scholar]
  9. Platts-Mills T. A., De Gast G. C., Webster A. D., Asherson G. L., Wilkins S. R. Two immunologically distinct forms of late-onset hypogammaglobulinaemia. Clin Exp Immunol. 1981 May;44(2):383–388. [PMC free article] [PubMed] [Google Scholar]
  10. Siegal F. P., Siegal M., Good R. A. Role of helper, suppressor and B-cell defects in the pathogenesis of the hypogammaglobulinemias. N Engl J Med. 1978 Jul 27;299(4):172–178. doi: 10.1056/NEJM197807272990404. [DOI] [PubMed] [Google Scholar]
  11. Souadjian J. V., Enriquez P., Silverstein M. N., Pépin J. M. The spectrum of diseases associated with thymoma. Coincidence or syndrome? Arch Intern Med. 1974 Aug;134(2):374–379. [PubMed] [Google Scholar]
  12. Waldmann T. A., Broder S., Durm M., Blackman M., Krakauer R., Meade B. Suppressor T cells in the pathogenesis of hypogammaglobulinemia associated with a thymoma. Trans Assoc Am Physicians. 1975;88:120–134. [PubMed] [Google Scholar]
  13. Waldmann T. A., Durm M., Broder S., Blackman M., Blaese R. M., Strober W. Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. Lancet. 1974 Sep 14;2(7881):609–613. doi: 10.1016/s0140-6736(74)91940-0. [DOI] [PubMed] [Google Scholar]
  14. de la Concha E. G., Oldham G., Webster A. D., Asherson G. L., Platts-Mills T. A. Quantitative measurements of T- and B-cell function in "variable" primary hypogammaglobulinaemia: evidence for a consistent B-cell defect. Clin Exp Immunol. 1977 Feb;27(2):208–215. [PMC free article] [PubMed] [Google Scholar]

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