Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1985 Dec;62(3):753–757.

The relationship between atopy and salivary IgA deficiency in infancy.

P P van Asperen, M Gleeson, A S Kemp, A W Cripps, S B Geraghty, C M Mellis, R L Clancy
PMCID: PMC1577475  PMID: 4085155

Abstract

In a prospective study, infants born to atopic parents had a significantly higher prevalence of salivary IgA deficiency at all ages studied than control infants, and the mean non zero IgA level of the potentially atopic infants was significantly lower at 8 and 12 months than of control infants. Of the infants with atopic parents, the prevalence of IgA deficiency was not significantly greater in those who manifested atopic disease during the study period than in those who did not, but the levels were significantly lower at 4 months.

Full text

PDF
756

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore) 1971 May;50(3):223–236. [PubMed] [Google Scholar]
  2. Brasher G. W. Salivary IgA children with atopic diseases. Ann Allergy. 1971 Aug;29(8):422–427. [PubMed] [Google Scholar]
  3. Buckley R. H., Dees S. C. Correlation of milk precipitins with IgA deficiency. N Engl J Med. 1969 Aug 28;281(9):465–469. doi: 10.1056/NEJM196908282810903. [DOI] [PubMed] [Google Scholar]
  4. Buckley R. H., Fiscus S. A. Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest. 1975 Jan;55(1):157–165. doi: 10.1172/JCI107906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Burgio G. R., Duse M., Monafo V., Ascione A., Nespoli L. Selective IgA deficiency: clinical and immunological evaluation of 50 pediatric patients. Eur J Pediatr. 1980 Mar;133(2):101–106. doi: 10.1007/BF00441577. [DOI] [PubMed] [Google Scholar]
  6. Burr M. L. Does infant feeding affect the risk of allergy? Arch Dis Child. 1983 Jul;58(7):561–565. doi: 10.1136/adc.58.7.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cogswell J. J., Halliday D. F., Alexander J. R. Respiratory infections in the first year of life in children at risk of developing atopy. Br Med J (Clin Res Ed) 1982 Apr 3;284(6321):1011–1013. doi: 10.1136/bmj.284.6321.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Detels R., Brody J. A., McNew J., Edgar A. H. Further epidemiological studies of subacute sclerosing panencephalitis. Lancet. 1973 Jul 7;2(7819):11–14. doi: 10.1016/s0140-6736(73)91946-6. [DOI] [PubMed] [Google Scholar]
  9. Frick O. L., German D. F., Mills J. Development of allergy in children. I. Association with virus infections. J Allergy Clin Immunol. 1979 Apr;63(4):228–241. doi: 10.1016/0091-6749(79)90106-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hobbs J. R. Immune imbalance in dysgammaglobulinaemia type IV. Lancet. 1968 Jan 20;1(7534):110–114. doi: 10.1016/s0140-6736(68)92721-9. [DOI] [PubMed] [Google Scholar]
  11. Hobday J. D., Cake M., Turner K. J. A comparison of the immunoglobulins IgA, IgG and IgE in nasal secretions from normal and asthmatic children. Clin Exp Immunol. 1971 Nov;9(5):577–583. [PMC free article] [PubMed] [Google Scholar]
  12. Jarrett E. E. Activation of IgE regulatory mechanisms by transmucosal absorption of antigen. Lancet. 1977 Jul 30;2(8031):223–225. doi: 10.1016/s0140-6736(77)92837-9. [DOI] [PubMed] [Google Scholar]
  13. Jarrett E. E. Perinatal influences on IgE responses. Lancet. 1984 Oct 6;2(8406):797–799. doi: 10.1016/s0140-6736(84)90716-5. [DOI] [PubMed] [Google Scholar]
  14. Kaufman H. S., Hobbs J. R. Immunoglobulin deficiencies in an atopic population. Lancet. 1970 Nov 21;2(7682):1061–1063. doi: 10.1016/s0140-6736(70)90288-6. [DOI] [PubMed] [Google Scholar]
  15. Ostergaard P. A., Blom M. Whole salivary immunoglobulin levels in 60 healthy children: determined by a sensitive electroimmuno technique after prior carbamylation. J Clin Chem Clin Biochem. 1977 Jul;15(7):393–396. doi: 10.1515/cclm.1977.15.1-12.393. [DOI] [PubMed] [Google Scholar]
  16. Pepys J. Skin tests for immediate, type I, allergic reactions. Proc R Soc Med. 1972 Mar;65(3):271–272. [PMC free article] [PubMed] [Google Scholar]
  17. Salvaggio J., Lopez M., Arquembourg P., Waldman R., Sly M. Salivary, nasal wash, and sputum IgA concentrations in atopic and nonatopic individuals. J Allergy Clin Immunol. 1973 Jun;51(6):335–343. doi: 10.1016/0091-6749(73)90072-9. [DOI] [PubMed] [Google Scholar]
  18. Savilahti E., Pelkonen P. Clinical findings and intestinal immunoglobulins in children with partial IgA deficiency. Acta Paediatr Scand. 1979 Jul;68(4):513–519. doi: 10.1111/j.1651-2227.1979.tb05049.x. [DOI] [PubMed] [Google Scholar]
  19. Savilahti E., Pelkonen P., Visakorpi J. K. IgA deficiency in children. A clinical study with special reference to intestinal findings. Arch Dis Child. 1971 Oct;46(249):665–670. doi: 10.1136/adc.46.249.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Siegler D. I., Citron K. M. Serum and parotid salivary IgA in chronic bronchitis and asthma. Thorax. 1974 May;29(3):313–316. doi: 10.1136/thx.29.3.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Soothill J. F., Stokes C. R., Turner M. W., Norman A. P., Taylor B. Predisposing factors and the development of reaginic allergy in infancy. Clin Allergy. 1976 Jul;6(4):305–319. doi: 10.1111/j.1365-2222.1976.tb01911.x. [DOI] [PubMed] [Google Scholar]
  22. Stiehm E. R., Fudenberg H. H. Serum levels of immune globulins in health and disease: a survey. Pediatrics. 1966 May;37(5):715–727. [PubMed] [Google Scholar]
  23. Van Asperen P. P., Kemp A. S., Mellis C. M. Relationship of diet in the development of atopy in infancy. Clin Allergy. 1984 Nov;14(6):525–532. doi: 10.1111/j.1365-2222.1984.tb02239.x. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES