Abstract
Mononuclear cells of the cerebrospinal fluid from a patient with multiple sclerosis were maintained in vitro for 5 days. Synthesis of IgG occurred and was significantly higher during a relapse of the disease than during remissions. The electrophoretic IgG species that were found in the cerebrospinal fluid of the patient were also synthesized in vitro.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cohen S., Bannister R. Immunoglobulin synthesis within the central nervous system in disseminated sclerosis. Lancet. 1967 Feb 8;1(7486):366–367. doi: 10.1016/s0140-6736(67)92900-5. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- WIEME R. J. An improved technique of agar-gel electrophoresis on microscope slides. Clin Chim Acta. 1959 May;4(3):317–321. doi: 10.1016/0009-8981(59)90096-8. [DOI] [PubMed] [Google Scholar]