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. 1969 Jan;4(1):93–100.

The effect of anti-lymphocytic IgG on unsensitized and sensitized spleen cells in vivo and in vitro

K James, Valerie S James, Diane M Pullar
PMCID: PMC1579061  PMID: 5786815

Abstract

Rat spleen cells sensitized to bovine serum albumin and treated in vitro with anti-lymphocytic IgG are unable to transfer secondary immunological (humoral) responsiveness to irradiated isogeneic rats. Similar in vitro treatment of unsensitized spleen cells has a significant, though less marked effect, upon their ability to confer primary humoral responsiveness to irradiated recipients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boak J. L., Fox M., Wilson R. E. Activity of lymphoid tissues from antilymphocyte-serum-treated mice. Lancet. 1967 Apr 8;1(7493):750–752. doi: 10.1016/s0140-6736(67)91366-9. [DOI] [PubMed] [Google Scholar]
  2. Boak J. L., Wilson R. E. Modification of the graft-versus-host syndrome by anti-lymphocyte serum treatment of the donor. Clin Exp Immunol. 1968 Oct;3(8):795–800. [PMC free article] [PubMed] [Google Scholar]
  3. Brent L., Courtenay T., Gowland G. Immunological reactivity of lymphoid cells after treatment with anti-lymphocytic serum. Nature. 1967 Sep 30;215(5109):1461–1464. doi: 10.1038/2151461a0. [DOI] [PubMed] [Google Scholar]
  4. DeMeester T. R., Anderson N. D., Shaffer C. F. The effect of heterologous anti-lymphocyte seerum on mouse hemopoietic stem cells. J Exp Med. 1968 Apr 1;127(4):731–748. doi: 10.1084/jem.127.4.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Denman A. M., Denman E. J., Holborow E. J. Suppression of Coombs-positive haemolytic anaemia in NZB mice by antilymphocyte globulin. Lancet. 1967 May 20;1(7499):1084–1086. doi: 10.1016/s0140-6736(67)92653-0. [DOI] [PubMed] [Google Scholar]
  6. FARR R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. doi: 10.1093/infdis/103.3.239. [DOI] [PubMed] [Google Scholar]
  7. Field E. O., Gibbs J. E. Cross-reaction of anti-lymphocyte serum with haemopoietic stem cells. Nature. 1968 Feb 10;217(5128):561–562. doi: 10.1038/217561a0. [DOI] [PubMed] [Google Scholar]
  8. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  9. Harris S., Harris T. N. Suppression of rabbit lymph node cells by rabbit anti-leucocyte serum demonstrated in vitro by the antibody plaque test. J Immunol. 1966 Mar;96(3):478–487. [PubMed] [Google Scholar]
  10. James K. Anti-lymphocytic antibody--a review. Clin Exp Immunol. 1967 Nov;2(6):615–631. [PMC free article] [PubMed] [Google Scholar]
  11. James K. In vivo and in vitro effect of anti-lymphocytic IgG on sensitized spleen cells. Nature. 1968 Jan 20;217(5125):261–262. doi: 10.1038/217261a0. [DOI] [PubMed] [Google Scholar]
  12. James K., Jubb V. S. Effect of anti-rat lymphocyte antibody on humoral antibody formation. Nature. 1967 Jul 22;215(5099):367–371. doi: 10.1038/215367a0. [DOI] [PubMed] [Google Scholar]
  13. James K. Some factors influencing the ability of anti-lymphocytic antibody to suppress humoral antibody formation. Clin Exp Immunol. 1967 Nov;2(6):685–690. [PMC free article] [PubMed] [Google Scholar]
  14. Levey R. H., Medawar P. B. Further experiments on the action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1967 Aug;58(2):470–477. doi: 10.1073/pnas.58.2.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Martin W. J., Miller J. F. Site of action of antilymphocyte globulin. Lancet. 1967 Dec 16;2(7529):1285–1287. doi: 10.1016/s0140-6736(67)90395-9. [DOI] [PubMed] [Google Scholar]
  16. Naysmith J. D., James K. Effect of F(ab')2 from rabbit anti-mouse lymphocyte IgG on the graft versus host reaction in F1 hybrid mice. Nature. 1968 Jan 20;217(5125):260–261. doi: 10.1038/217260a0. [DOI] [PubMed] [Google Scholar]

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