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. 1969 May;4(5):537–553.

The metabolism of autologous IgM and 19S rheumatoid factor in rheumatoid arthritis

J Bradley, D Normansell, D S Rowe
PMCID: PMC1579068  PMID: 5787345

Abstract

The turnover of autologous preparations of radio-iodine labelled IgM and 19S rheumatoid factor was studied and compared in patients with severe rheumatoid disease. The IgM was isolated by block electrophoresis and column chromatography. 19S rheumatoid factor was isolated by a combination of euglobulin precipitation, column chromatography, and absorption onto and acid-elution from solid aggregated IgG.

Ten studies were made in seven patients, five with IgM, and five with 19S rheumatoid factor. In two patients the turnovers of 19S rheumatoid factor and IgM were studied simultaneously.

The turnover of IgM was similar to that reported for normal subjects and patients with other diseases: fractional catabolic rate 0·14–0·18, plasma and whole body T½ 3·7–6·5 days, with 65–77% intravascular localization. The absolute catabolic rate for IgM was elevated (8–60 mg/kg/day).

The turnover of 19S rheumatoid factor isolated from serum was comparable in fractional catabolic rate (0·15–0·19) plasma and whole body T½ (3·9–6·0 days) and intravascular localization (62–88%). No evidence of rapid catabolism of the `immune' elimination type was obtained.

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Selected References

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