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. 1969 Jul;5(1):17–27.

Studies on the immunology of human malaria. II. Characterization of antibodies to Plasmodium falciparum infections

M W Turner, I A McGregor
PMCID: PMC1579091  PMID: 4892613

Abstract

Gel precipitin and fluorescent antibodies to human Plasmodium falciparum malaria have been investigated using techniques of comparative immunoelectrophoresis, gel-filtration and DEAE-cellulose chromatography. Antibody activity was generally associated with the IgG class but some gel precipitin antibodies of IgM type were identified. Findings in regard to antibody activity in the IgA class were inconclusive.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELE D. C., TOBIE J. E., HILL G. J., CONTACOS P. G., EVANS C. B. ALTERATIONS IN SERUM PROTEINS AND 19S ANTIBODY PRODUCTION DURING THE COURSE OF INDUCED MALARIAL INFECTIONS IN MAN. Am J Trop Med Hyg. 1965 Mar;14:191–197. doi: 10.4269/ajtmh.1965.14.191. [DOI] [PubMed] [Google Scholar]
  2. Brown K. N., Brown I. N. Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature. 1965 Dec 25;208(5017):1286–1288. doi: 10.1038/2081286a0. [DOI] [PubMed] [Google Scholar]
  3. COHEN S., McGREGOR I. A., CARRINGTON S. Gamma-globulin and acquired immunity to human malaria. Nature. 1961 Nov 25;192:733–737. doi: 10.1038/192733a0. [DOI] [PubMed] [Google Scholar]
  4. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  5. FAHEY J. L., MCLAUGHLIN C. PREPARATION OF ANTISERA SPECIFIC FOR 6.6 S GAMMA-GLOBULINS, BETA 2A-GLOBULINS, GAMMA-1.-MACROGLOBULINS, AND FOR TYPE I AND II COMMON GAMMA-GLOBULIN DETERMINANTS. J Immunol. 1963 Oct;91:484–497. [PubMed] [Google Scholar]
  6. GRABAR P., WILLIAMS C. A. Méthode permettant l'étude conjuguée des proprietés électrophorétiques et immunochimiques d'un mélange de protéines; application au sérum sanguin. Biochim Biophys Acta. 1953 Jan;10(1):193–194. doi: 10.1016/0006-3002(53)90233-9. [DOI] [PubMed] [Google Scholar]
  7. MCGREGOR I. A., WILLIAMS K., VOLLER A., BILLEWICZ W. Z. IMMUNOFLUORESCENCE AND THE MEASUREMENT OF IMMUNE RESPONSE TO HYPERENDEMIC MALARIA. Trans R Soc Trop Med Hyg. 1965 Jul;59:395–414. doi: 10.1016/0035-9203(65)90057-x. [DOI] [PubMed] [Google Scholar]
  8. Mahoney D. F., Redington B. C., Schoenbechler M. J. The preparation and serologic activity of plasmodial fractions. Mil Med. 1966 Sep;131(9 Suppl):1141–1151. [PubMed] [Google Scholar]
  9. McGregor I. A., Hall P. J., Williams K., Hardy C. L. Demonstration of circulating antibodies to Plasmodium falciparum by gel-diffusion techniques. Nature. 1966 Jun 25;210(5043):1384–1386. doi: 10.1038/2101384a0. [DOI] [PubMed] [Google Scholar]
  10. OUCHTERLONY O. Diffusion-in-gel methods for immunological analysis. Prog Allergy. 1958;5:1–78. [PubMed] [Google Scholar]
  11. ROCKEY J. H., KUNKEL H. G. Unusual sedimentation and sulfhydryl sensitivity of certain isohemagglutinins and skin-sensitizing antibody. Proc Soc Exp Biol Med. 1962 May;110:101–105. doi: 10.3181/00379727-110-27437. [DOI] [PubMed] [Google Scholar]
  12. Rowe D. S., McGregor I. A., Smith S. J., Hall P., Williams K. Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults. Clin Exp Immunol. 1968 Jan;3(1):63–79. [PMC free article] [PubMed] [Google Scholar]
  13. STEIN B., DESOWITZ R. S. THE MEASUREMENT OF ANTIBODY IN HUMAN MALARIA BY A FORMOLIZED TANNED SHEEP CELL HAEMAGGLUTINATION TEST. Bull World Health Organ. 1964;30:45–49. [PMC free article] [PubMed] [Google Scholar]
  14. TERRY W. D. SUBCLASSES OF HUMAN IG G MOLECULES DIFFERING IN HETEROLOGOUS SKIN SENSITZING PROPERTIES. Proc Soc Exp Biol Med. 1964 Dec;117:901–904. doi: 10.3181/00379727-117-29732. [DOI] [PubMed] [Google Scholar]
  15. TOBIE J. E., COATNEY G. R. Fluorescent antibody staining of human malaria parasites. Exp Parasitol. 1961 Sep;11:128–132. doi: 10.1016/0014-4894(61)90017-0. [DOI] [PubMed] [Google Scholar]
  16. Turner M. W., McGregor I. A. Studies on the immunology of human malaria. I. Preliminary characterization of antigens in Plasmodium falciparum infections. Clin Exp Immunol. 1969 Jul;5(1):1–16. [PMC free article] [PubMed] [Google Scholar]
  17. Turner M. W., Voller A. Studies on immunoglobulins of Nigerians. I. The immunoglobulin levels of a Nigerian population. J Trop Med Hyg. 1966 May;69(5):99–103. [PubMed] [Google Scholar]
  18. VOLLER A. FLUORESCENT ANTIBODY METHODS AND THEIR USE IN MALARIA RESEARCH. Bull World Health Organ. 1964;30:343–354. [PMC free article] [PubMed] [Google Scholar]

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