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. 1969 Sep;5(3):251–263.

Increased 7S antibody response to sheep erythrocytes in the 2-month-old NZB mouse

J Baum
PMCID: PMC1579108  PMID: 5810150

Abstract

The validity of the use of the NZB mouse as a model for systemic lupus erythematosus is supported by a study of the 7S and 19S antibody response to immunization with sheep erythrocytes. In comparison with CBA and C3H mice the 2-month-old NZB animals made significantly more whole serum antibody. DBA, C57BL and A/Jax animals made about the same amount of whole serum antibody. Compared to all the control groups the NZB animals made significantly more 7S antibody in eight of twenty examinations of 2-mercaptoethanol resistant antibody studied from 1 to 8 weeks after immunization. Old NZB animals showed the same degree of 7S antibody production as the 2-month-old animals and were no different from a group of old White Swiss mice. The NZB animals thus show early immunological hyperreactivity most prominently in the 7S immunoglobulin fraction at a time when virtually no autoantibodies are present.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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