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. 1966 Apr;1(2):223–231.

Acquired dysgammaglobulinaemia in a young man

R T Williams
PMCID: PMC1579179  PMID: 5915326

Abstract

A 26-year-old man had been subject to repeated infections since the age of 15. He was found to have complete absence of isohaemagglutinins, even though he was blood group O, and absence of antibodies to any of the common bacterial and viral infections. A full course of typhoid–paratyphoid A and B vaccine produced no antibody response and a large dose of inactivated poliomyelitis vaccine produced only a minimal response. Estimation of the immunoglobulin levels in the serum revealed a normal amount of IgG globulin, increased amounts of IgM globulin and diminished amounts of IgA globulin.

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Selected References

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  1. BRUTON O. C. Agammaglobulinemia. Pediatrics. 1952 Jun;9(6):722–728. [PubMed] [Google Scholar]
  2. BURTIN P. [An example of atypical agammaglobulinemia (a case of severe hypogammaglobulinemia with increase of the beta-2 macroglobulin]. Rev Fr Etud Clin Biol. 1961 Mar;6:286–289. [PubMed] [Google Scholar]
  3. CITRON K. M. Agammaglobulinaemia with splenomegaly. Br Med J. 1957 May 18;1(5028):1148–1151. doi: 10.1136/bmj.1.5028.1148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CUTBUSH M., MOLLISON P. L. Relation between characteristics of blood-group antibodies in vitro and associated patterns of redcell destruction in vivo. Br J Haematol. 1958 Apr;4(2):115–137. doi: 10.1111/j.1365-2141.1958.tb03843.x. [DOI] [PubMed] [Google Scholar]
  5. ELVES M. W., ISRAUELS M. C. CHROMOSOMES AND SERUM PROTEINS: A LINKED ABNORMALITY. Br Med J. 1963 Oct 26;2(5364):1024–1026. doi: 10.1136/bmj.2.5364.1024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GIEDION A., SCHEIDEGGER J. J. Kongenitale Immunparese bei Fehlen spezifischer beta 2-Globuline und quantitativ normalen gamma-Globulinen. Helv Paediatr Acta. 1957 Aug;12(3):241–259. [PubMed] [Google Scholar]
  7. GILBERT C., HONG R. QUALITATIVE AND QUANTITATIVE IMMUNOGLOBULIN DEFICIENCY. Am J Med. 1964 Oct;37:602–609. doi: 10.1016/0002-9343(64)90072-5. [DOI] [PubMed] [Google Scholar]
  8. GITLIN D., ROSEN F. S., JANEWAY C. A. Undue susceptibility to infection. Pediatr Clin North Am. 1962 May;9:405–423. doi: 10.1016/s0031-3955(16)31263-9. [DOI] [PubMed] [Google Scholar]
  9. GOOD R. A., ZAK S. J., CONDIE R. M., BRIDGES R. A. Clinical investigation of patients with agammaglobulinemia and hypogammaglobulinemia. Pediatr Clin North Am. 1960 May;7:397–433. doi: 10.1016/s0031-3955(16)30945-2. [DOI] [PubMed] [Google Scholar]
  10. HEREMANS J. F., VAERMAN J. P. Beta-2A-Globulin as a possible carrier of allergic reaginic activity. Nature. 1962 Mar 17;193:1091–1092. doi: 10.1038/1931091b0. [DOI] [PubMed] [Google Scholar]
  11. HINZ C. F., BOYER J. T. DYSGAMMAGLOBULINEMIA IN THE ADULT MANIFESTED AS AUTOIMMUNE HEMOLYTIC ANEMIA. SEROLOGIC AND IMMUNOCHEMICAL CHARACTERIZATION OF AN ANTIBODY OF UNUSUAL SPECIFICITY. N Engl J Med. 1963 Dec 19;269:1329–1335. doi: 10.1056/NEJM196312192692501. [DOI] [PubMed] [Google Scholar]
  12. HONG R., SCHUBERT W. K., PERRIN E. V., WEST C. D. Antibody deficiency syndrome associated with beta-2 macroglobulinemia. J Pediatr. 1962 Dec;61:831–842. doi: 10.1016/s0022-3476(62)80193-0. [DOI] [PubMed] [Google Scholar]
  13. HUNGERFORD D. A., DONNELLY A. J., NOWELL P. C., BECK S. The chromosome constitution of a human phenotypic intersex. Am J Hum Genet. 1959 Sep;11:215–236. [PMC free article] [PubMed] [Google Scholar]
  14. HUNTLEY C. C., LAFFERTY J. W., LYERLY A. ANTIBODY DEFICIENCY SYNDROME WITH INCREASED GAMMA1 M (B2 M) GLOBULINS AND ABSENT GAMMA1 A (B2 A) GLOBULINS AND GAMMA2 (G) GLOBULINS. Pediatrics. 1963 Sep;32:407–415. [PubMed] [Google Scholar]
  15. ISRAEL-ASSELAIN R., BURTIN P., CHEBAT J. [A new biological disorder: agammaglobulinemia with beta2-macroglobulinemia (a case)]. Bull Mem Soc Med Hop Paris. 1960 Apr 1;76:519–523. [PubMed] [Google Scholar]
  16. KEKWICK R. A., VALLET L., CUTBUSH M., MOLLISON P. L., THOMAS A. R., GELL P. G., SOOTHILL J. F. Estimation of gamma globulin in the serum of patients with hypogammaglobulinaemia. J Clin Pathol. 1961 Sep;14:470–477. doi: 10.1136/jcp.14.5.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. LAWSON H. A., STUART C. A., PAULL A. M., PHILIPS A. M., PHILIPS R. W. Observations on the antibody content of the blood in patients with multiple myeloma. N Engl J Med. 1955 Jan 6;252(1):13–18. doi: 10.1056/NEJM195501062520103. [DOI] [PubMed] [Google Scholar]
  18. OSSERMAN E. F., TAKATSUKI K. PLASMA CELL MYELOMA: GAMMA GLOBULIN SYNTHESIS AND STRUCTURE. A REVIEW OF BIOCHEMICAL AND CLINICAL DATA, WITH THE DESCRIPTION OF A NEWLY-RECOGNIZED AND RELATED SYNDROME, "H-GAMMA-2-CHAIN (FRANKLIN'S) DISEASE. Medicine (Baltimore) 1963 Nov;42:357–384. [PubMed] [Google Scholar]
  19. RATCLIFF P., SOOTHILL J. F., STANWORTH D. R. Physicochemical and immunological studies of pathological serum macroglobulins. Clin Chim Acta. 1963 Jan;8:91–108. doi: 10.1016/0009-8981(63)90204-3. [DOI] [PubMed] [Google Scholar]
  20. ROSEN F. S., BOUGAS J. A. ACQUIRED DYSGAMMAGLOBULINEMIA: ELEVATION OF THE 19S GAMMA GLOBULIN AND DEFICIENCY OF THE 7S GAMMA GLOBULIN IN A WOMAN WITH CHRONIC PROGRESSIVE BRONCHIECTASIS. N Engl J Med. 1963 Dec 19;269:1336–1340. doi: 10.1056/NEJM196312192692502. [DOI] [PubMed] [Google Scholar]
  21. ROSEN F. S., KEVY S. V., MERLER E., JANEWAY C. A., GITLIN D. Recurrent bacterial infections and dysgamma-globulinemia: deficiency of 7S gamma-globulins in the presence of elevated 19S gamma-globulins. Report of two cases. Pediatrics. 1961 Aug;28:182–195. [PubMed] [Google Scholar]
  22. SOOTHILL J. F. Estimation of eight serum proteins by a gel diffusion precipitin technique. J Lab Clin Med. 1962 May;59:859–870. [PubMed] [Google Scholar]
  23. TURNER M. W., ROWE D. S. CHARACTERIZATION OF HUMAN ANTIBODIES TO SALMONELLA TYPHI BY GEL-FILTRATION AND ANTIGENIC ANALYSIS. Immunology. 1964 Nov;7:639–656. [PMC free article] [PubMed] [Google Scholar]
  24. ZINNEMAN H. H., HALL W. H. Recurrent pneumonia in multiple myeloma and some observations on immunologic response. Ann Intern Med. 1954 Dec;41(6):1152–1163. doi: 10.7326/0003-4819-41-6-1152. [DOI] [PubMed] [Google Scholar]

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