Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1966 Jul;1(3):323–335.

Split tolerance affecting delayed hypersensitivity and induced in mice by pre-immunization with protein antigens in solution

A J Crowle, C C Hu
PMCID: PMC1579198  PMID: 5911906

Abstract

Adult immunocompetent mice vaccinated with protein antigens in water-in-oil emulsion so as to develop immediate and delayed hypersensitivities resist developing the latter if they are treated with the immunizing antigen in aqueous solution before or during the sensitization period. If the treatments are given during or after vaccination this resistance is directly proportional to their intensity and inversely proportional to the degree of hypersensitivity which has developed when they are begun. But when the treatments are given before vaccination such split tolerance is more pronounced and seems to be directly proportional more to the degree of humoral antibody production existing at the time of vaccination than to the intensity of treatments. The characteristics of this antigenically specific selective unresponsiveness suggest that it may result from a competitive maturation or differentiation of primitive immunocytes: upon exposure to protein antigens in forms not readily able to induce delayed hypersensitivity, the potential functions of these immunocytes for making circulating antibodies may be pre-empted at the expense of such capacity to develop into cells making the antibody of delayed hypersensitivity.

Full text

PDF
331

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALVORD E. C., Jr, SHAW C. M., HRUBY S., KIES M. W. ENCEPHALITOGEN-INDUCED INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PREVENTION, SUPPRESSION AND THERAPY. Ann N Y Acad Sci. 1965 Mar 31;122:333–345. doi: 10.1111/j.1749-6632.1965.tb20218.x. [DOI] [PubMed] [Google Scholar]
  2. ARNASON B. G., WAKSMAN B. H. TUBERCULIN SENSITIVITY. IMMUNOLOGIC CONSIDERATIONS. Bibl Tuberc. 1964;19:1–97. [PubMed] [Google Scholar]
  3. Asherson G. L., Stone S. H. Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy. Immunology. 1965 Sep;9(3):205–217. [PMC free article] [PubMed] [Google Scholar]
  4. BATTISTO J. R., MILLER J. Immunological unresponsiveness produced in adult guinea pigs by parenteral introduction of minute quantities of hapten or protein antigen. Proc Soc Exp Biol Med. 1962 Oct;111:111–115. doi: 10.3181/00379727-111-27717. [DOI] [PubMed] [Google Scholar]
  5. BOWSER R. T., BAER H. CONTACT SENSITIVITY AND IMMUNOLOGIC UNRESPONSIVENESS IN ADULT GUINEA PIGS TO A COMPONENT OF POISON IVY EXTRACT, 3-N-PENTADECYLCATECHOL. J Immunol. 1963 Dec;91:791–794. [PubMed] [Google Scholar]
  6. BOYDEN S. V. The effect of previous injections of tuberculoprotein on the development of tuberculin sensitivity following B.C.G. vaccination in guinea-pigs. Br J Exp Pathol. 1957 Dec;38(6):611–617. [PMC free article] [PubMed] [Google Scholar]
  7. BRENT L. Tissue transplantation immunity. Prog Allergy. 1958;5:271–348. [PubMed] [Google Scholar]
  8. CROWLE A. J., HU C. C. INHIBITION OF THE DEVELOPMENT OF DELAYED HYPERSENSITIVITY BY TREATMENT WITH ANTISERUM. J Immunol. 1965 Apr;94:555–562. [PubMed] [Google Scholar]
  9. CROWLE A. J., HU C. C. TUBERCLE BACILLARY EXTRACTS IMMUNOGENIC FOR MICE. 7. ELECTROPHORETIC ANALYSES. Tubercle. 1965 Jun;46:214–223. doi: 10.1016/s0041-3879(65)80066-6. [DOI] [PubMed] [Google Scholar]
  10. CROWLE A. J. IMMUNOLOGIC UNRESPONSIVENESS TO PROTEIN ANTIGENS INDUCED IN ADULT HYPERSENSITIVE MICE. J Allergy. 1963 Nov-Dec;34:504–519. doi: 10.1016/0021-8707(63)90092-3. [DOI] [PubMed] [Google Scholar]
  11. CROWLE A. J. Specific immunologic unresponsiveness to delayed hypersensitivity elicited in adult mice. Proc Soc Exp Biol Med. 1962 Jul;110:447–449. doi: 10.3181/00379727-110-27545. [DOI] [PubMed] [Google Scholar]
  12. DORNER M. M., UHR J. W. IMMUNOLOGIC TOLERANCE AFTER SPECIFIC IMMUNIZATION. J Exp Med. 1964 Sep 1;120:435–447. doi: 10.1084/jem.120.3.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. DRESSER D. W. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology. 1962 May;5:378–388. [PMC free article] [PubMed] [Google Scholar]
  14. DVORAK H. F., BILLOTE J. B., MCCARTHY J. S., FLAX M. H. IMMUNOLOGIC UNRESPONSIVENESS IN THE ADULT GUINEA PIG. I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS. J Immunol. 1965 Jun;94:966–975. [PubMed] [Google Scholar]
  15. EISEN H. N., KARUSH F. IMMUNE TOLERANCE AND AN EXTRACELLULAR REGULATORY ROLE FOR BIVALENT ANTIBODY. Nature. 1964 May 16;202:677–682. doi: 10.1038/202677a0. [DOI] [PubMed] [Google Scholar]
  16. FREY J. R., DE WECK A. L., GELEICK H. IMMUNOLOGICAL UNRESPONSIVENESS IN ALLERGIC CONTACT DEMATITIS TO DINITROCHLOROBENZENE IN GUINEA PIGS. J Invest Dermatol. 1964 Jan;42:41–47. doi: 10.1038/jid.1964.11. [DOI] [PubMed] [Google Scholar]
  17. HARDIN C. A., WERDER A. A. Effect of skin extracts on the viability of homologous skin grafts in mice. Ann N Y Acad Sci. 1955 Jan 24;59(3):381–384. doi: 10.1111/j.1749-6632.1955.tb45951.x. [DOI] [PubMed] [Google Scholar]
  18. KATSH G. F., TALMAGE D. W., KATSH S. ACCEPTANCE OR REJECTION OF MALE SKIN BY ISOLOGOUS FEMALE MICE: EFFECT OF INJECTION OF SPERM. Science. 1964 Jan 3;143(3601):41–42. doi: 10.1126/science.143.3601.41. [DOI] [PubMed] [Google Scholar]
  19. SHAW C. M., ALVORD E. C., Jr, FAHLBERG W. J., KIES M. W. Specificity of encephalitogen-induced inhibition of experimental "allergic" encephalomyelitis in the guinea pig. J Immunol. 1962 Jul;89:54–61. [PubMed] [Google Scholar]
  20. SHAW C. M., ALVORD E. C., Jr, KAKU J., KIES M. W. CORRELATION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WITH DELAYED-TYPE SKIN SENSITIVITY TO SPECIFIC HOMOLOGOUS ENCEPHALITOGEN. Ann N Y Acad Sci. 1965 Mar 31;122:318–331. doi: 10.1111/j.1749-6632.1965.tb20216.x. [DOI] [PubMed] [Google Scholar]
  21. Talmage D. W., Pearlman D. S. The antibody response: a model based on antagonistic actions of antigen. J Theor Biol. 1963 Sep;5(2):321–339. doi: 10.1016/0022-5193(63)90067-5. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES