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. 1973 Feb 24;1(5851):449–451. doi: 10.1136/bmj.1.5851.449

Effect of Oestrogen Therapy on Plasma and Urinary Levels of Uric Acid

Anne Nicholls, M L Snaith, J T Scott
PMCID: PMC1588487  PMID: 4689833

Abstract

Uric acid clearance studies were carried out on a low-purine diet in 22 trans-sexual men before and during oestrogen therapy for this condition (stilboestrol in 21 cases, ethinyloestradiol in one). Plasma uric acid fell in 15 of the subjects and urinary uric acid rose in 17 of 20 subjects in whom satisfactory collections were obtained. These changes are significant and it is suggested that hormonal influences are responsible for the known age and sex differences in plasma uric acid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHESTERMAN F. C., FRANKS L. M., KNUDSEN E. T., WILLIAMS P. C. Possible aldosteronism in stilboestrol-treated guinea pigs. Lancet. 1956 Dec 8;271(6954):1192–1193. doi: 10.1016/s0140-6736(56)90059-9. [DOI] [PubMed] [Google Scholar]
  2. DANCE P., LLOYD S., PICKFORD M. The effects of stilboestrol on the renal activity of conscious dogs. J Physiol. 1959 Mar 3;145(2):225–240. doi: 10.1113/jphysiol.1959.sp006138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DIGNAM W. S., VOSKIAN J., ASSALI N. S. Effects of estrogens on renal hemodynamics and excretion of electrolytes in human subjects. J Clin Endocrinol Metab. 1956 Aug;16(8):1032–1042. doi: 10.1210/jcem-16-8-1032. [DOI] [PubMed] [Google Scholar]
  4. GRABER-DUVERNAY J., GRABER-DUVERNAY B. A propos de la goutte aigue féminine. Rhumatologie. 1957 Nov-Dec;41(6):261–267. [PubMed] [Google Scholar]
  5. GUTMAN A. B., YU T. F. A three-component system for regulation of renal excretion of uric acid in man. Trans Assoc Am Physicians. 1961;74:353–365. [PubMed] [Google Scholar]
  6. HORNING E. S., WHITTICK J. W. The histogenesis of stilboestrol-induced renal tumours in the male golden hamster. Br J Cancer. 1954 Sep;8(3):451–457. doi: 10.1038/bjc.1954.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LEEPER R. D., BENUA R. S., BRENER J. L., RAWSON R. W. Hyperuricemia in myxedema. J Clin Endocrinol Metab. 1960 Nov;20:1457–1466. doi: 10.1210/jcem-20-11-1457. [DOI] [PubMed] [Google Scholar]
  8. LIDDLE L., SEEGMILLER J. E., LASTER L. The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med. 1959 Dec;54:903–913. [PubMed] [Google Scholar]
  9. LLAURADO J. G., CLAUS J. L., TRUNNELL J. B. Aldosterone excretion in feces of rats treated with estradiol. Endocrinology. 1962 Oct;71:598–604. doi: 10.1210/endo-71-4-598. [DOI] [PubMed] [Google Scholar]
  10. MIKKELSEN W. M., DODGE H. J., VALKENBURG H. THE DISTRIBUTION OF SERUM URIC ACID VALUES IN A POPULATION UNSELECTED AS TO GOUT OR HYPERURICEMIA: TECUMSEH, MICHIGAN 1959-1960. Am J Med. 1965 Aug;39:242–251. doi: 10.1016/0002-9343(65)90048-3. [DOI] [PubMed] [Google Scholar]
  11. MINTZ D. H., CANARY J. J., CARREON G., KYLE L. H. Hyperuricemia in hyperparathyroidism. N Engl J Med. 1961 Jul 20;265:112–115. doi: 10.1056/NEJM196107202650302. [DOI] [PubMed] [Google Scholar]
  12. PREEDY J. R., AITKEN E. H. The effect of estrogen on water and electrolyte metabolism. I. The normal. J Clin Invest. 1956 Apr;35(4):423–429. doi: 10.1172/JCI103293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SCOTT J. T., DIXON A. S., BYWATERS E. G. ASSOCIATION OF HYPERURICAEMIA AND GOUT WITH HYPERPARATHYROIDISM. Br Med J. 1964 Apr 25;1(5390):1070–1073. doi: 10.1136/bmj.1.5390.1070. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Scott J. T., Pollard A. C. Uric acid excretion in the relatives of patients with gout. Ann Rheum Dis. 1970 Jul;29(4):397–400. doi: 10.1136/ard.29.4.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. TREVAN D. Glomerular changes induced by stilboestrol. Lancet. 1956 Jul 7;271(6932):22–23. doi: 10.1016/s0140-6736(56)91391-5. [DOI] [PubMed] [Google Scholar]

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