Abstract
Investigation of 20 patients with skeletal fluorosis showed that five had clear evidence of secondary hyperparathyroidism. The hyperactivity of the parathyroid glands in skeletal fluorosis in the presence of decreased solubility of the bone mineral (fluoroapatite) strongly suggests that it is a compensatory attempt to maintain a normal extracellular ionized calcium equilibrium. Further study of the parathyroid glands and of bone lesions in skeletal fluorosis is in progress.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bernstein D. S., Cohen P. Use of sodium fluoride in the treatment of osteoporosis. J Clin Endocrinol Metab. 1967 Feb;27(2):197–210. doi: 10.1210/jcem-27-2-197. [DOI] [PubMed] [Google Scholar]
- Davies D. R., Dent C. E., Watson L. Tertiary hyperparathyroidism. Br Med J. 1968 Aug 17;3(5615):395–399. doi: 10.1136/bmj.3.5615.395. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Faccini J. M., Care A. D. Effect of sodium fluoride on the ultrastructure of the parathyroid glands of the sheep. Nature. 1965 Sep 25;207(5004):1399–1401. doi: 10.1038/2071399a0. [DOI] [PubMed] [Google Scholar]
- Faccini J. M. Fluoride and bone. Calcif Tissue Res. 1969;3(1):1–16. doi: 10.1007/BF02058641. [DOI] [PubMed] [Google Scholar]
- Havivi E., Guggenheim K. The effect of copper and fluoride on the bone of mice treated with parathryoid hormone. J Endocrinol. 1966 Dec;36(4):357–361. doi: 10.1677/joe.0.0360357. [DOI] [PubMed] [Google Scholar]
- PROFFIT W. R., ACKERMAN J. L. FLUORIDE: ITS EFFECTS ON 2 PARAMETERS OF BONE GROWTH IN ORGAN CULTURE. Science. 1964 Aug 28;145(3635):932–934. doi: 10.1126/science.145.3635.932. [DOI] [PubMed] [Google Scholar]
- ROCKERT H., SUNZEL H. Skeletal lesions following ingestion of fluoridated water. Experientia. 1960 Apr 15;16:155–156. doi: 10.1007/BF02157731. [DOI] [PubMed] [Google Scholar]
- Teotia M., Teotia S. P., Kunwar K. B. Endemic skeletal fluorosis. Arch Dis Child. 1971 Oct;46(249):686–691. doi: 10.1136/adc.46.249.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
- YATES C., DOTY S., TALMAGE R. V. EFFECTS OF SODIUM FLUORIDE ON CALCIUM HOMEOSTASIS. Proc Soc Exp Biol Med. 1964 Apr;115:1103–1108. doi: 10.3181/00379727-115-29127. [DOI] [PubMed] [Google Scholar]
- ZIPKIN I., SCHRAER R., SCHRAER H., LEE W. A. The effect of fluoride on the citrate content of the bones of the growing rat. Arch Oral Biol. 1963 Mar-Apr;8:119–126. doi: 10.1016/0003-9969(63)90049-9. [DOI] [PubMed] [Google Scholar]