Abstract
A comparative trial of co-trimoxazole and chloramphenicol was conducted in two groups of 50 patients each to try to resolve conflicting opinions on the relative merits of the two drugs in the treatment of typhoid fever. We conclude that in our part of India co-trimoxazole is superior to chloramphenicol and that differences in our findings to those of others may perhaps be accounted for by differences in strains of Salmonella typhi, ethnic differences, and possibly differences in herd immunity to typhoid.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Akinkugbe O. O., Lewis E. A., Montefiore D., Okubadejo O. A. Trimethoprim and sulphamethoxazole in typhoid. Br Med J. 1968 Sep 21;3(5620):721–722. doi: 10.1136/bmj.3.5620.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farid Z., Hassan A., Wahab M. F., Sanborn W. R., Kent D. C., Hathout S. E. Trimethoprim-sulphamethoxazole in enteric fevers. Br Med J. 1970 Aug 8;3(5718):323–324. doi: 10.1136/bmj.3.5718.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Geddes A. M., Fothergill R., Goodall J. A., Dorken P. R. Evaluation of trimethoprim-sulphamethoxazole compound in treatment of salmonella infections. Br Med J. 1971 Aug;3(5772):451–454. doi: 10.1136/bmj.3.5772.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kamat S. A. Evaluation of therapeutic efficacy of trimethoprim-sulphamethoxazole and chloramphenicol in enteric fever. Br Med J. 1970 Aug 8;3(5718):320–322. doi: 10.1136/bmj.3.5718.320. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sardesai H. V., Melinkere R. D., Diwate A. B. Trimethoprim-sulphamethoxazole in typhoid fever. Trans R Soc Trop Med Hyg. 1971;65(2):189–194. doi: 10.1016/0035-9203(71)90216-1. [DOI] [PubMed] [Google Scholar]
- Scragg J. N., Rubidge C. J. Trimethoprim and sulphamethoxazole in typhoid fever in children. Br Med J. 1971 Sep 25;3(5777):738–741. doi: 10.1136/bmj.3.5777.738. [DOI] [PMC free article] [PubMed] [Google Scholar]