Abstract
Plasma prostaglandin F2α (PGF2α) concentrations were measured by radioimmunoassay in women in normal first stage labour. A continuous sampling technique was used spanning uterine contractions, and blood samples were divided into 15-second aliquots.
A regular pattern of rise in prostaglandin levels in peripheral plasma was observed, with maximum concentrations in the antecubital vein being reached in most cases 15-45 seconds after the peak of a uterine contraction. The most likely explanation of this finding is that prostaglandins are released as a result of uterine contractions. The alternative possibility is that prostaglandins initiate uterine contractions. Further studies of the time taken for blood to reach the antecubital vein are needed to clarify the position.
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Selected References
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- Beazley J. M., Gillespie A. Double-bli trial of prostaglandin E2 and oxytocin in induction of labour. Lancet. 1971 Jan 23;1(7691):152–155. doi: 10.1016/s0140-6736(71)91931-3. [DOI] [PubMed] [Google Scholar]
- Karim S. M. Appearance of prostaglandin F2-alpha in human blood during labour. Br Med J. 1968 Dec 7;4(5631):618–621. doi: 10.1136/bmj.4.5631.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karim S. Action of prostaglandin in the pregnant woman. Ann N Y Acad Sci. 1971 Apr 30;180:483–498. doi: 10.1111/j.1749-6632.1971.tb53216.x. [DOI] [PubMed] [Google Scholar]
- Sharma S. C. A sensitive radioimmune assay for prostaglandins F. J Physiol. 1972 Oct;226(2):74P–75P. [PubMed] [Google Scholar]