Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1973 Mar 31;1(5856):765–768. doi: 10.1136/bmj.1.5856.765

Double-blind Trial of Linoleate Supplementation of the Diet in Multiple Sclerosis

J H D Millar, K J Zilkha, M J S Langman, H Payling Wright, A D Smith, J Belin, R H S Thompson
PMCID: PMC1588925  PMID: 4571680

Abstract

Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.

Full text

PDF
768

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON R. S. Some neurological aspects of medical geography. Proc R Soc Med. 1963 Feb;56:71–76. [PMC free article] [PubMed] [Google Scholar]
  2. Alling C., Vanier M. T., Svennerholm L. Lipid alterations in apparently normal white matter in multiple sclerosis. Brain Res. 1971 Dec 24;35(2):325–336. doi: 10.1016/0006-8993(71)90478-1. [DOI] [PubMed] [Google Scholar]
  3. Arnetoli G., Pazzagli A., Amaducci L. Fatty acid and aldehyde changes in choline- and ethanolamine-containing phospholipids in the white matter of multiple sclerosis brains. J Neurochem. 1969 Mar;16(3):461–463. doi: 10.1111/j.1471-4159.1969.tb10387.x. [DOI] [PubMed] [Google Scholar]
  4. BAKER R. W., THOMPSON R. H., ZILKHA K. J. Fatty-acid composition of brain lecithins in multiple sclerosis. Lancet. 1963 Jan 5;1(7271):26–27. doi: 10.1016/s0140-6736(63)91152-8. [DOI] [PubMed] [Google Scholar]
  5. BAKER R. W., THOMPSON R. H., ZILKHA K. J. SERUM FATTY ACIDS IN MULTIPLE SCLEROSIS. J Neurol Neurosurg Psychiatry. 1964 Oct;27:408–414. doi: 10.1136/jnnp.27.5.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Caspary E. A., Prineas J., Miller H., Field E. J. Platelet stickiness in multiple sclerosis. Lancet. 1965 Nov 27;2(7422):1108–1109. doi: 10.1016/s0140-6736(65)90068-1. [DOI] [PubMed] [Google Scholar]
  7. Clausen J., Hansen I. B. Myelin constituents of human central nervous system. Acta Neurol Scand. 1970;46(1):1–17. doi: 10.1111/j.1600-0404.1970.tb05601.x. [DOI] [PubMed] [Google Scholar]
  8. Cumings J. N., Shortman R. C., Skrbic T. Lipid studies in the blood and brain in multiple sclerosis and motor neurone disease. J Clin Pathol. 1965 Sep;18(5):641–644. doi: 10.1136/jcp.18.5.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GERSTL B., KAHNKE M. J., SMITH J. K., TAVASTSTJERNA M. G., HAYMAN R. B. Brain lipids in multiple sclerosis and other diseases. Brain. 1961 Jun;84:310–319. doi: 10.1093/brain/84.2.310. [DOI] [PubMed] [Google Scholar]
  10. Gerstl B., Eng L. F., Tavaststjerna M., Smith J. K., Kruse S. L. Lipids and proteins in multiple sclerosis white matter. J Neurochem. 1970 May;17(5):677–689. doi: 10.1111/j.1471-4159.1970.tb00547.x. [DOI] [PubMed] [Google Scholar]
  11. Gul S., Smith A. D., Thompson R. H., Wright H. P., Zilkha K. J. Fatty acid composition of phospholipids from platelets and erythrocytes in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):506–510. doi: 10.1136/jnnp.33.4.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KURTZKE J. F. On the evaluation of disability in multiple sclerosis. Neurology. 1961 Aug;11:686–694. doi: 10.1212/wnl.11.8.686. [DOI] [PubMed] [Google Scholar]
  13. Millar J. H., Merrett J. D., Dalby A. M. Platelet stickiness in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1966 Jun;29(3):187–189. doi: 10.1136/jnnp.29.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Millar J. H., Vas C. J., Noronha M. J., Liversedge L. A., Rawson M. D. Long-term treatment of multiple sclerosis with corticotrophin. Lancet. 1967 Aug 26;2(7513):429–431. doi: 10.1016/s0140-6736(67)90850-1. [DOI] [PubMed] [Google Scholar]
  15. SINCLAIR H. M. Deficiency of essential fatty acids and atherosclerosis, etcetera. Lancet. 1956 Apr 7;270(6919):381–383. [PubMed] [Google Scholar]
  16. SWANK R. L. Multiple sclerosis; a correlation of its incidence with dietary fat. Am J Med Sci. 1950 Oct;220(4):421–430. [PubMed] [Google Scholar]
  17. Sanders H., Thompson R. H., Wright H. P., Zilkha K. J. Further studies on platelet adhesiveness and serum cholesteryl linoleate levels in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1968 Aug;31(4):321–325. doi: 10.1136/jnnp.31.4.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Swank R. L. Multiple sclerosis: twenty years on low fat diet. Arch Neurol. 1970 Nov;23(5):460–474. doi: 10.1001/archneur.1970.00480290080009. [DOI] [PubMed] [Google Scholar]
  19. Tichý J., Vymazal J., Michalec C. Serum lipoproteins, cholesterol esters and phospholipids in multiple sclerosis. Acta Neurol Scand. 1969;45(1):32–40. doi: 10.1111/j.1600-0404.1969.tb01217.x. [DOI] [PubMed] [Google Scholar]
  20. Wright H. P., Thompson R. H., Zilkha K. J. Platelet adhesiveness in multiple sclerosis. Lancet. 1965 Nov 27;2(7422):1109–1110. doi: 10.1016/s0140-6736(65)90069-3. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES