Abstract
Frequencies of the thalassaemias in Cyprus were examined by a survey of hospital inpatients and haematological investigations of adult and newborn population samples. The data indicate that 15% of the Greek and Turkish Cypriots are carriers of beta-thalassaemia genes, while 10% of the population carry alpha-thalassaemia genes. These are the highest frequencies of thalassaemia genes found today in any Caucasian population.
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- Abramson R. K., Rucknagel D. L., Shreffler D. C., Saave J. J. Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians. Science. 1970 Jul 10;169(3941):194–196. doi: 10.1126/science.169.3941.194. [DOI] [PubMed] [Google Scholar]
- BETKE K., MARTI H. R., SCHLICHT I. Estimation of small percentages of foetal haemoglobin. Nature. 1959 Dec 12;184(Suppl 24):1877–1878. doi: 10.1038/1841877a0. [DOI] [PubMed] [Google Scholar]
- Beaven G. H., Hornabrook R. W., Fox R. H., Huehns E. R. Occurrence of heterozygotes and homozygotes for the alpha-chain haemoglobin variant Hb-J(Tongariki) in New Guinea. Nature. 1972 Jan 7;235(5332):46–47. doi: 10.1038/235046a0. [DOI] [PubMed] [Google Scholar]
- Carter C. O., Roberts J. A., Evans K. A., Buck A. R. Genetic clinic. A follow-up. Lancet. 1971 Feb 6;1(7693):281–285. doi: 10.1016/s0140-6736(71)91016-6. [DOI] [PubMed] [Google Scholar]
- Clegg J. B., Weatherall D. J., Milner P. F. Haemoglobin Constant Spring--a chain termination mutant? Nature. 1971 Dec 10;234(5328):337–340. doi: 10.1038/234337a0. [DOI] [PubMed] [Google Scholar]
- DIAMOND M. P., COTGROVE I., PARKER A. CASE OF INTRAUTERINE DEATH DUE TO ALPHA-THALASSAEMIA. Br Med J. 1965 Jul 31;2(5456):278–279. doi: 10.1136/bmj.2.5456.278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOUTTAS A., FESSAS P., TSEVRENIS H., XEFTERI E. Description d'une nouvelle variété d'anémie hémolytique congénitale; etude hématologique, électrophorétique et génétique. Sang. 1955;26(9):911–919. [PubMed] [Google Scholar]
- Hollán S. R., Szelenyi J. G., Brimhall G., Duerst M., Jones R. T., Koler R. D., Stocklen Z. Multiple alpha chain loci for human haemoglobins: Hb J-Buda and Hb G-Pest. Nature. 1972 Jan 7;235(5332):47–50. doi: 10.1038/235047a0. [DOI] [PubMed] [Google Scholar]
- Kattamis C., Haidas S., Metaxotou-Mavromati A., Matsaniotis N. Beta-thalassaemia, G-6-PD deficiency, and atypical cholinesterase in Cyprus. Br Med J. 1972 Aug 19;3(5824):470–471. doi: 10.1136/bmj.3.5824.470-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koler R. D., Jones R. T., Wasi P., Pootrukul S. Genetics of haemoglobin H and alpha-thalassaemia. Ann Hum Genet. 1971 May;34(4):371–377. doi: 10.1111/j.1469-1809.1971.tb00249.x. [DOI] [PubMed] [Google Scholar]
- Lehmann H., Carrell R. W. Differences between alpha- and beta-chain mutants of human haemoglobin and between alpha- and beta-thalassaemia. Possible duplication of the alpha-chain gene. Br Med J. 1968 Dec 21;4(5633):748–750. doi: 10.1136/bmj.4.5633.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lehmann H. Different types of alpha-thalassaemia and significance of haemoglobin Bart's in neonates. Lancet. 1970 Jul 11;1(7663):78–80. doi: 10.1016/s0140-6736(70)92645-0. [DOI] [PubMed] [Google Scholar]
- Modell C. B., Benson A., Wright C. R. Incidence of -thalassaemia trait among Cypriots in London. Br Med J. 1972 Sep 23;3(5829):737–738. doi: 10.1136/bmj.3.5829.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PLATO C. C., RUCKNAGEL D. L., GERSHOWITZ H. STUDIES ON THE DISTRIBUTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY, THALASSEMIA, AND OTHER GENETIC TRAITS IN THE COASTAL AND MOUNTAIN VILLAGES OF CYPRUS. Am J Hum Genet. 1964 Sep;16:267–283. [PMC free article] [PubMed] [Google Scholar]