Abstract
A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The blood pressure can be controlled and the symptoms alleviated promptly by alpha and beta adrenergic receptor blockade using intravenous phentolamine and propranolol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ABBOUD F. M., ECKSTEIN J. W. EFFECTS OF SMALL ORAL DOSES OF RESERPINE ON VASCULAR RESPONSES TO TYRAMINE AND NOREPINEPHRINE IN MAN. Circulation. 1964 Feb;29:219–223. doi: 10.1161/01.cir.29.2.219. [DOI] [PubMed] [Google Scholar]
- Hökfelt B., Hedeland H., Dymling J. F. Studies on catecholamines, renin and aldosterone following Catapresan (2-(2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patients. Eur J Pharmacol. 1970;10(3):389–397. doi: 10.1016/0014-2999(70)90212-8. [DOI] [PubMed] [Google Scholar]
- Parsons W. B., Jr, Morledge J. H. Antihypertensive effect of a new imidazoline compound (clonidine) and chlorthalidone, individually and in combination. Am J Cardiol. 1970 Sep;26(3):258–261. doi: 10.1016/0002-9149(70)90792-7. [DOI] [PubMed] [Google Scholar]
- Putzeys M. R., Hoobler S. W. Comparison of clonidine and methyldopa on blood pressure and side effects in hypertensive patients. Am Heart J. 1972 Apr;83(4):464–468. doi: 10.1016/0002-8703(72)90036-1. [DOI] [PubMed] [Google Scholar]
- Raftos J. The use of "Catapres" in the treatment of severe hypertension. Med J Aust. 1969 Oct 4;2(14):684–687. doi: 10.5694/j.1326-5377.1969.tb107345.x. [DOI] [PubMed] [Google Scholar]
- Smet G., Hoobler S. W., Sanbar S., Julis S. Clinical observations on a new antihypertensive drug, 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride. Am Heart J. 1969 Apr;77(4):473–478. doi: 10.1016/0002-8703(69)90156-2. [DOI] [PubMed] [Google Scholar]
- von EULER U., LISHAJKO F. Improved technique for the fluorimetric estimation of catecholamines. Acta Physiol Scand. 1961 Apr;51:348–355. doi: 10.1111/j.1748-1716.1961.tb02128.x. [DOI] [PubMed] [Google Scholar]