Abstract
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6 mg/kg/day) was in the normal range, but that of cephalothin (180 mg/kg/day) was abnormally high. The nephropathy was of the tubular-interstitial type and the clinical picture similar to that seen in acute drug-induced nephropathies. Frusemide was given only after the onset of renal failure. In these three patients the high intravenous doses of cephalothin combined with gentamicin were probably nephrotoxic.
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Selected References
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- BULGER R. J., SIDELL S., KIRBY W. M. LABORATORY AND CLINICAL STUDIES OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC. Ann Intern Med. 1963 Nov;59:593–604. doi: 10.7326/0003-4819-59-5-593. [DOI] [PubMed] [Google Scholar]
- Linton A. L., Bailey R. R., Turnbull D. I. Relative nephrotoxicity of cephalosporin antibiotics in an animal model. Can Med Assoc J. 1972 Sep 9;107(5):414–416. [PMC free article] [PubMed] [Google Scholar]
- Opitz A., Herrmann I., van Herrath D., Schaefer K. Akute Niereninsuffizienz nach Gentamycin-Cephalosporin-Kombinationstherapie. Med Welt. 1971 Mar 13;11:434–438. [PubMed] [Google Scholar]
- Pickering M. J., Spooner G. R., de Quesada A., Cade J. R. Declining renal function associated with administration of cephalothin. South Med J. 1970 Apr;63(4):426–428. doi: 10.1097/00007611-197004000-00020. [DOI] [PubMed] [Google Scholar]
- Rahal J. J., Jr, Meyers B. R., Weinstein L. Treatment of bacterial endocarditis with cephalothin. N Engl J Med. 1968 Dec 12;279(24):1305–1309. doi: 10.1056/NEJM196812122792403. [DOI] [PubMed] [Google Scholar]
- Simpson I. J. Nephrotoxicity and acute renal failure associated with cephalothin and cephaloridine. N Z Med J. 1971 Nov;74(474):312–315. [PubMed] [Google Scholar]