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. 1978 Aug 26;2(6137):594–596. doi: 10.1136/bmj.2.6137.594

Hepatitis B in a hospital for the mentally subnormal in southern England.

J G Kingham, M McGuire, D H Paine, R Wright
PMCID: PMC1607487  PMID: 151573

Abstract

The prevalence of hepatitis B viral (HBV) infection was assessed in 340 patients and 268 staff in a hospital for the mentally subnormal in Wessex. Hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen, antibody to HBsAg, e antigen (eAg), and antibody to eAg were used as markers of such infection. Forty patients and 10 staff had evidence of recent or current infection, while 149 patients and 50 staff had evidence of past infection. HBV markers were more common in mongols, epileptics, patients with cerebral palsy, and those of lower mental grades and reached a peak after 5-15 years of hospitalisation. eAg was detected in 12 out of 26 patients with HBsAg but in none of the four staff with HBsAg. Abnormal liver function values were found in 24 (60%) of the patients with recent or current HBV infection but in only 30 (19%) of those without HBV markers. Among the staff the prevalence of HBV markers correlated with the duration of employment and degree of contact with patients. Of those with recent or current infection, 4 (40%) had abnormal liver function values compared with 25 (12%) of those without HBV markers. Despite the high prevalence of markers clinically overt hepatitis B was rare.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumberg B. S., Gerstley B. J., Hungerford D. A., London W. T., Sutnick A. I. A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann Intern Med. 1967 May;66(5):924–931. doi: 10.7326/0003-4819-66-5-924. [DOI] [PubMed] [Google Scholar]
  2. Eleftheriou N., Thomas H. C., Heathcote J., Sherlock S. Incidence and clinical significance of e antigen and antibody in acute and chronic liver disease. Lancet. 1975 Dec 13;2(7946):1171–1173. doi: 10.1016/s0140-6736(75)92657-4. [DOI] [PubMed] [Google Scholar]
  3. Feinman S. V., Berris B., Sinclair J. C., Wrobel D. M., Murphy B. L., Maynard J. E. e antigen and anti-e in HBsAg carriers. Lancet. 1975 Dec 13;2(7946):1173–1174. doi: 10.1016/s0140-6736(75)92658-6. [DOI] [PubMed] [Google Scholar]
  4. Goodman M., Wainright R. L., Weir H. F., Gall J. C., Jr A sex difference in the carrier state of Australia (hepatitis-associated) antigen. Pediatrics. 1971 Dec;48(6):907–913. [PubMed] [Google Scholar]
  5. Hoofnagle J. H., Gerety R. J., Ni L. Y., Barker L. F. Antibody to hepatitis B core antigen. A sensitive indicator of hepatitis B virus replication. N Engl J Med. 1974 Jun 13;290(24):1336–1340. doi: 10.1056/NEJM197406132902402. [DOI] [PubMed] [Google Scholar]
  6. Krugman S., Giles J. P. Viral hepatitis. New light on an old disease. JAMA. 1970 May 11;212(6):1019–1029. doi: 10.1001/jama.212.6.1019. [DOI] [PubMed] [Google Scholar]
  7. Magnius L. O., Espmark J. A. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol. 1972 Nov;109(5):1017–1021. [PubMed] [Google Scholar]
  8. Magnius L. O., Lindholm A., Lundin P., Iwarson S. A new antigen-antibody system. Clinical significance in long-term carriers of hepatitis B surface antigen. JAMA. 1975 Jan 27;231(4):356–359. doi: 10.1001/jama.231.4.356. [DOI] [PubMed] [Google Scholar]
  9. Melartin L., Panelius M. Occurrence of Australia antigen in Finnish mongolism patients. Ann Med Exp Biol Fenn. 1967;45(2):157–158. [PubMed] [Google Scholar]
  10. Nielsen J. O., Dietrichson O., Juhl E. Incidence and meaning of the "e" determinant among hepatitis-B-antigen positive patients with acute and chronic liver diseases. Report from the Copenhagen Hepatitis Acuta Programme. Lancet. 1974 Oct 19;2(7886):913–915. doi: 10.1016/s0140-6736(74)91127-1. [DOI] [PubMed] [Google Scholar]
  11. Sutnick A. I., London W. T., Gerstley B. J., Cronlund M. M., Blumberg B. S. Anicteric hepatitis associated with Australia antigen. Occurrence in patients with Down's syndrome. JAMA. 1968 Sep 2;205(10):670–674. [PubMed] [Google Scholar]
  12. Szmuness W., Pick R., Prince A. M. The serum hepatitis virus specific antigen (SH): a preliminary report of epidemiologic studies in an institution for the mentally retarded. Am J Epidemiol. 1970 Jul;92(1):51–61. doi: 10.1093/oxfordjournals.aje.a121179. [DOI] [PubMed] [Google Scholar]
  13. Szmuness W., Prince A. M., Etling G. F., Pick R. Development and distribution of hemagglutinating antibody against the hepatitis B antigen in institutionalized populations. J Infect Dis. 1972 Nov;126(5):498–506. doi: 10.1093/infdis/126.5.498. [DOI] [PubMed] [Google Scholar]

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