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. 1978 Oct 7;2(6143):994–996. doi: 10.1136/bmj.2.6143.994

Dexamethasone in acute stroke.

G Mulley, R G Wilcox, J R Mitchell
PMCID: PMC1607934  PMID: 361156

Abstract

Over 13 months 118 patients admitted to hospital with acute stroke were allocated at random to treatment with either dexamethasone or placebo. At one year there was no significant difference in the numbers of survivors or in the quality of life between the two groups. The results suggest that there is no indication for the routine administration of dexamethasone to a heterogeneous group of patients with stroke.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer R. B., Tellez H. Dexamethasone as treatment in cerebrovascular disease. 2. A controlled study in acute cerebral infarction. Stroke. 1973 Jul-Aug;4(4):547–555. doi: 10.1161/01.str.4.4.547. [DOI] [PubMed] [Google Scholar]
  2. Candelise L., Colombo A., Spinnler H. Letter: Anti-oedema treatment of completed stroke. Lancet. 1974 Apr 27;1(7861):806–806. doi: 10.1016/s0140-6736(74)92873-6. [DOI] [PubMed] [Google Scholar]
  3. Ng L. K., Nimmannitya J. Massive cerebral infarction with severe brain swelling: a clinicopathological study. Stroke. 1970 May-Jun;1(3):158–163. doi: 10.1161/01.str.1.3.158. [DOI] [PubMed] [Google Scholar]
  4. Norris J. W. Steroid therapy in acute cerebral infarction. Arch Neurol. 1976 Jan;33(1):69–71. doi: 10.1001/archneur.1976.00500010071014. [DOI] [PubMed] [Google Scholar]
  5. Patten B. M., Mendell J., Bruun B., Curtin W., Carter S. Double-blind study of the effects of dexamethasone on acute stroke. Neurology. 1972 Apr;22(4):377–383. doi: 10.1212/wnl.22.4.377. [DOI] [PubMed] [Google Scholar]
  6. RUSSEK H. I., RUSSEK A. S., ZOHMAN B. L. Cortisone in immediate therapy of apoplectic stroke. J Am Med Assoc. 1955 Sep 10;159(2):102–105. doi: 10.1001/jama.1955.02960190008003. [DOI] [PubMed] [Google Scholar]
  7. Rubinstein M. K. The influence of adrenocortical steroids on severe cerebrovascular accidents. J Nerv Ment Dis. 1965 Sep;141(3):291–299. doi: 10.1097/00005053-196509000-00005. [DOI] [PubMed] [Google Scholar]
  8. SHEELY R. F., JOHNSON C. H., BAKER J. J., HARBAUGH R. Effect of cortisone and hydrocortisone in hemiplegia after cerebral infarction. I. Preliminary report, with special reference to spasticity. J Am Med Assoc. 1955 Jul 9;158(10):803–806. doi: 10.1001/jama.1955.02960100001001. [DOI] [PubMed] [Google Scholar]

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