Abstract
Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy. In both patients choreo-athetoid involuntary movements were prominent. Blood phenytoin concentrations were above 30 μg/ml. When phenytoin was given in smaller doses and its level in the blood fell the involuntary movements and other clinical manifestations disappeared.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERGIN J. T., FISCHER E., MORRIS J. V. Rare complication of phenytoin sodium treatment. Br Med J. 1956 Dec 29;2(5008):1529–1529. doi: 10.1136/bmj.2.5008.1529. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BUCHTHAL F., SVENSMARK O., SCHILLER P. J. Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin. Arch Neurol. 1960 Jun;2:624–630. doi: 10.1001/archneur.1960.03840120030004. [DOI] [PubMed] [Google Scholar]
- Hansen J. M., Kristensen M., Skovsted L. Sulthiame (Ospolot) as inhibitor of diphenylhydatoin metabolism. Epilepsia. 1968 Mar;9(1):17–22. doi: 10.1111/j.1528-1157.1968.tb04954.x. [DOI] [PubMed] [Google Scholar]
- KOKENGE R., KUTT H., MCDOWELL F. NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS. Neurology. 1965 Sep;15:823–829. doi: 10.1212/wnl.15.9.823. [DOI] [PubMed] [Google Scholar]
- LEVY L. L., FENICHEL G. M. DIPHENYLHYDANTOIN ACTIVATED SEIZURES. Neurology. 1965 Aug;15:716–722. doi: 10.1212/wnl.15.8.719. [DOI] [PubMed] [Google Scholar]
- Logan W. J., Freeman J. M. Pseudodegenerative disease due to diphenylhydantoin intoxication. Arch Neurol. 1969 Dec;21(6):631–637. doi: 10.1001/archneur.1969.00480180087008. [DOI] [PubMed] [Google Scholar]
- ROSEMAN E. Dilantin toxicity. A clinical and electroence-phalographic study. Neurology. 1961 Oct;11:912–921. doi: 10.1212/wnl.11.10.912. [DOI] [PubMed] [Google Scholar]