Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1974 Oct 12;4(5936):79–82. doi: 10.1136/bmj.4.5936.79

Combined T and B Cell Acute Lymphoblastic Leukaemia

D G Haegert, J C Cawley, A Karpas, A H Goldstone
PMCID: PMC1612151  PMID: 4606364

Abstract

A case of acute lymphoblastic leukaemia in a 17-year-old male is described. The patient had many distinctive features including a very high blast cell count, prominent lymphadenopathy and hepatosplenomegaly, thymic mass, and a fulminant clinical course. Immunological studies on the blast cells using a variety of techniques showed the presence of two distinct subpopulations, one having the surface characteristics of thymus-dependent (T) lymphoid cells and the other those of bursa-equivalent (B) lymphoid cells. The case therefore represents the first example of a combined T and B cell acute leukaemia.

Full text

PDF
81

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aisenberg A. C., Bloch K. J. Immunoglobulins on the surface of neoplastic lymphocytes. N Engl J Med. 1972 Aug 10;287(6):272–276. doi: 10.1056/NEJM197208102870603. [DOI] [PubMed] [Google Scholar]
  2. Belpomme D., Dantchev D., Du Rusquec E., Grandjon D., Huchet R., Pouillart P., Schwarzenberg L., Amiel J. L., Mathé G. T and B lymphocyte markers on the neoplastic cell of 20 patients with acute and 10 patients with chronic lymphoid leukemia. Biomedicine. 1974 Mar;20(2):109–118. [PubMed] [Google Scholar]
  3. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Borella L., Sen L. T cell surface markers on lymphoblasts from acute lymphocytic leukemia. J Immunol. 1973 Oct;111(4):1257–1260. [PubMed] [Google Scholar]
  5. Catovsky D., Galetto J., Okos A., Galton D. A., Wiltshaw E., Stathopoulos G. Prolymphocytic leukaemia of B and T cell type. Lancet. 1973 Aug 4;2(7823):232–234. doi: 10.1016/s0140-6736(73)93135-8. [DOI] [PubMed] [Google Scholar]
  6. Chin A. H., Saiki J. H., Trujillo J. M., Williams R. C., Jr Peripheral blood T- and B-lymphocytes in patients with lymphoma and acute leukemia. Clin Immunol Immunopathol. 1973 Jul;1(4):499–510. doi: 10.1016/0090-1229(73)90006-8. [DOI] [PubMed] [Google Scholar]
  7. Dickler H. B., Adkinson N. F., Jr, Terry W. D. Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers. Nature. 1974 Jan 25;247(5438):213–215. doi: 10.1038/247213a0. [DOI] [PubMed] [Google Scholar]
  8. Haegert D. G., Hallberg T., Coombs R. R. B and T lymphocyte subpopulations in human peripheral blood. Int Arch Allergy Appl Immunol. 1974;46(4):525–538. doi: 10.1159/000231155. [DOI] [PubMed] [Google Scholar]
  9. Hallberg T., Gurner B. W., Coombs R. R. Opsonic adherence of sensitized ox red cells to human lymphocytes as measured by rosette formation. Int Arch Allergy Appl Immunol. 1973;44(4):500–513. doi: 10.1159/000230956. [DOI] [PubMed] [Google Scholar]
  10. Hallberg T., Haegert D., Clein G. P., Coombs R. R., Feinstein A., Gurner B. W. Observations on the mixed antiglobulin reaction as a test for immunoglobulin-bearing lymphocytes in normal persons and in patients with chronic lymphatic leukaemia. J Immunol Methods. 1974 Mar;4(2):317–332. doi: 10.1016/0022-1759(74)90074-x. [DOI] [PubMed] [Google Scholar]
  11. Jaffe E. S., Shevach E. M., Frank M. M., Berard C. W., Green I. Nodular lymphoma--evidence for origin from follicular B lymphocytes. N Engl J Med. 1974 Apr 11;290(15):813–819. doi: 10.1056/NEJM197404112901501. [DOI] [PubMed] [Google Scholar]
  12. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kersey J. H., Sabad A., Gajl-Peczalska K., Hallgren H. M., Yunis E. J., Nesbit M. E. Acute lymphoblastic leukemic cells with T (thymus-derived) lymphocyte markers. Science. 1973 Dec 28;182(4119):1355–1356. doi: 10.1126/science.182.4119.1355. [DOI] [PubMed] [Google Scholar]
  14. Lay W. H., Mendes N. F., Bianco C., Nussenzweig V. Binding of sheep red blood cells to a large population of human lymphocytes. Nature. 1971 Apr 23;230(5295):531–532. doi: 10.1038/230531a0. [DOI] [PubMed] [Google Scholar]
  15. Lille I., Desplaces A., Meeus L., Saracino R. T., Brouet J. C. Thymus-derived proliferating lymphocytes in chronic lymphocytic leukaemia. Lancet. 1973 Aug 4;2(7823):263–264. doi: 10.1016/s0140-6736(73)93170-x. [DOI] [PubMed] [Google Scholar]
  16. Michlmayr G., Huber H. Receptor sites for complement on certain human peripheral blood lymphocytes. J Immunol. 1970 Sep;105(3):670–676. [PubMed] [Google Scholar]
  17. Minowada J., Onuma T., Moore G. E. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst. 1972 Sep;49(3):891–895. [PubMed] [Google Scholar]
  18. Raff M. C. T and B lymphocytes and immune responses. Nature. 1973 Mar 2;242(5392):19–23. doi: 10.1038/242019a0. [DOI] [PubMed] [Google Scholar]
  19. Sandilands G. P., Gray K., Cooney A., Browning J. D., Grant R. M., Anderson J. R., Dagg J. H., Lucie N. Lymphocytes with T and B cell properties in a lymphoproliferative disorder. Lancet. 1974 May 11;1(7863):903–904. doi: 10.1016/s0140-6736(74)90350-x. [DOI] [PubMed] [Google Scholar]
  20. Shevach E. M., Herberman R., Frank M. M., Green I. Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines. J Clin Invest. 1972 Aug;51(8):1933–1938. doi: 10.1172/JCI106999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wilson J. D., Nossal G. J. Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukaemia. Lancet. 1971 Oct 9;2(7728):788–791. doi: 10.1016/s0140-6736(71)92741-3. [DOI] [PubMed] [Google Scholar]
  22. Wybran J., Chantler S., Fudenberg H. H. Isolation of normal T cells in chronic lymphatic leukaemia. Lancet. 1973 Jan 20;1(7795):126–129. doi: 10.1016/s0140-6736(73)90196-7. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES