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. 1974 Dec 7;4(5944):564–566. doi: 10.1136/bmj.4.5944.564

Plasma Trytophan and Sleep

C N Chen, R S Kalucy, M K Hartmann, J H Lacey, A H Crisp, J E Bailey, E G Eccleston, A Coppen
PMCID: PMC1612687  PMID: 4373116

Abstract

Free, bound, and total plasma tryptophan (F.P.T., B.P.T., and T.P.T.) levels have been measured throughout the night in six young female volunteers. All-night polygraphic sleep recordings were also made. No direct temporal relationship was found between plasma tryptophan levels and specific sleep stages. The mean F.P.T. levels, however, were found to have a positive correlation with rapid-eye-movement (R.E.M.) sleep and a negative correlation with non-R.E.M. sleep. An inverse relationship existed between the F.P.T. and B.P.T. levels. There appeared to be a diurnal variation in F.P.T. levels, with high readings in the first half of the night.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aylward M., Maddock J. Plasma-tryptophan levels in depression. Lancet. 1973 Apr 28;1(7809):936–936. doi: 10.1016/s0140-6736(73)91389-5. [DOI] [PubMed] [Google Scholar]
  2. Brezinová V., Oswald I. Sleep after a bedtime beverage. Br Med J. 1972 May 20;2(5811):431–433. doi: 10.1136/bmj.2.5811.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coppen A., Brooksbank B. W., Peet M. Tryptophan concentration in the cerebrospinal fluid of depressive patients. Lancet. 1972 Jun 24;1(7765):1393–1393. doi: 10.1016/s0140-6736(72)91123-3. [DOI] [PubMed] [Google Scholar]
  4. Coppen A., Eccleston E. G., Peet M. Total and free tryptophan concentration in the plasma of depressive patients. Lancet. 1973 Jul 14;2(7820):60–63. doi: 10.1016/s0140-6736(73)93259-5. [DOI] [PubMed] [Google Scholar]
  5. Crisp A. H., Stonehill E. Aspects of the relationship between sleep and nutrition: a study of 375 psychiatric out-patients. Br J Psychiatry. 1973 Apr;122(569):379–394. doi: 10.1192/bjp.122.4.379. [DOI] [PubMed] [Google Scholar]
  6. Crisp A. H., Stonehill E., Fenton G. W. The relationship between sleep, nutrition and mood: a study of patients with anorexia nervosa. Postgrad Med J. 1971 Apr;47(546):207–213. doi: 10.1136/pgmj.47.546.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Curzon G., Friedel J., Knott P. J. The effect of fatty acids on the binding of tryptophan to plasma protein. Nature. 1973 Mar 16;242(5394):198–200. doi: 10.1038/242198a0. [DOI] [PubMed] [Google Scholar]
  8. Curzon G., Knott P. J. Drugs influencing plasma and brain tryptophan. Br J Pharmacol. 1973 Jun;48(2):352P–353P. [PMC free article] [PubMed] [Google Scholar]
  9. Eccleston E. G. A method for the estimation of free and total acid-soluble plasma tryptophan using an ultrafiltration technique. Clin Chim Acta. 1973 Oct 30;48(3):269–272. doi: 10.1016/0009-8981(73)90195-2. [DOI] [PubMed] [Google Scholar]
  10. Fernstrom J. D., Wurtman R. J. Nutrition and the brain. Sci Am. 1974 Feb;230(2):84–91. [PubMed] [Google Scholar]
  11. KNOX W. E., AUERBACH V. H. The hormonal control of tryptophan peroxidase in the rat. J Biol Chem. 1955 May;214(1):307–313. [PubMed] [Google Scholar]
  12. Knott P. J., Curzon G. Free tryptophan in plasma and brain tryptophan metabolism. Nature. 1972 Oct 20;239(5373):452–453. doi: 10.1038/239452a0. [DOI] [PubMed] [Google Scholar]
  13. Korf J., Van Praag H. M., Sebens J. B. Serum tryptophan decreased, brain tryptophan increased and brain serotonin synthesis unchanged after probenecid loading. Brain Res. 1972 Jul 13;42(1):239–242. doi: 10.1016/0006-8993(72)90062-5. [DOI] [PubMed] [Google Scholar]
  14. Moir A. T., Eccleston D. The effects of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J Neurochem. 1968 Oct;15(10):1093–1108. doi: 10.1111/j.1471-4159.1968.tb06827.x. [DOI] [PubMed] [Google Scholar]
  15. Southwell P. R., Evans C. R., Hunt J. N. Effect of a hot milk drink on movements during sleep. Br Med J. 1972 May 20;2(5811):429–431. doi: 10.1136/bmj.2.5811.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sukkar M. Y., Hunter W. M., Passmore R. Changes in plasma levels of insulin and growth-hormone levels after a protein meal. Lancet. 1967 Nov 11;2(7524):1020–1022. doi: 10.1016/s0140-6736(67)90291-7. [DOI] [PubMed] [Google Scholar]
  17. Tagliamonte A., Tagliamonte P., Perez-Cruet J., Gessa G. L. Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. Nat New Biol. 1971 Jan 27;229(4):125–126. doi: 10.1038/newbio229125a0. [DOI] [PubMed] [Google Scholar]
  18. Wyatt R. J., Engelman K., Kupfer D. J., Fram D. H., Sjoerdsma A., Snyder F. Effects of L-tryptophan (a natural sedative) on human sleep. Lancet. 1970 Oct 24;2(7678):842–846. doi: 10.1016/s0140-6736(70)92015-5. [DOI] [PubMed] [Google Scholar]
  19. Wyatt R. J., Engelman K., Kupfer D. J., Scott J., Sjoerdsma A., Snyder F. Effects of para-chlorophenylalanine on sleep in man. Electroencephalogr Clin Neurophysiol. 1969 Nov;27(5):529–532. doi: 10.1016/0013-4694(69)90193-x. [DOI] [PubMed] [Google Scholar]

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