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. 1974 Aug 10;3(5927):400, 401-402. doi: 10.1136/bmj.3.5927.400

Complications of Carbenoxolone Therapy

G J Davies, J Rhodes, B J Calcraft
PMCID: PMC1613145  PMID: 4851128

Abstract

Side effects from carbenoxolone are common and are due to electrolyte disturbance, such as sodium retention and hypokalaemia. They occur particularly in the elderly, who may already be being treated for other illnesses. Eight patients are described with serious side effects from carbenoxolone therapy, some of which were unrecognized for some time because of inadequate follow-up or because clinicians were unfamiliar with them.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cliff J. M., Milton-Thompson G. J. A double-blind trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. Gut. 1970 Feb;11(2):167–170. doi: 10.1136/gut.11.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DOLL R., HILL I. D., HUTTON C. F. TREATMENT OF GASTRIC ULCER WITH CARBENOXOLONE SODIUM AND OESTROGENS. Gut. 1965 Feb;6:19–24. doi: 10.1136/gut.6.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Doll R., Langman M. J., Shawdon H. H. Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone. Gut. 1968 Feb;9(1):42–45. doi: 10.1136/gut.9.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hausmann W., Tárnoky A. L. Biochemical effects of short-term treatment with carbenoxolone disodium. Br J Pharmacol Chemother. 1966 Feb;26(2):412–420. doi: 10.1111/j.1476-5381.1966.tb01921.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Horwich L., Galloway R. Treatment of gastric ulceration with carbenoxolone sodium: clinical and radiological evaluation. Br Med J. 1965 Nov 27;2(5473):1274–1277. doi: 10.1136/bmj.2.5473.1274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mohamed S. D., Chapman R. S., Crooks J. Hypokalaemia, flaccid quadruparesis, and myoglobinuria with carbenoxolone (biogastrone). Br Med J. 1966 Jun 25;1(5503):1581–1582. doi: 10.1136/bmj.1.5503.1581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Montgomery R. D. Side effects of carbenoxolone sodium: a study of ambulant therapy of gastric ulcer. Gut. 1967 Apr;8(2):148–150. doi: 10.1136/gut.8.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Muir A., Laithwaite J. A., Wood W. Hypokalaemia complicating carbenoxolone (duogastrone) therapy. Br Med J. 1969 May 24;2(5655):512–513. doi: 10.1136/bmj.2.5655.512-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Swallow M. Hypokalemia after treatment with duogastrone (carbenoxolone). Br Med J. 1969 Jul 26;3(5664):238–239. doi: 10.1136/bmj.3.5664.238-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Turpie A. G., Thomson T. J. Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut. 1965 Dec;6(6):591–594. doi: 10.1136/gut.6.6.591. [DOI] [PMC free article] [PubMed] [Google Scholar]

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