Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1960 Sep;152(3):354–372.

The Homotransplantation of Kidneys and of Fetal Liver and Spleen after Total Body Irradiation *

David M Hume, Benjamin T Jackson, Charles F Zukoski, H M Lee, H Myron Kauffman, Richard H Egdahl
PMCID: PMC1613686  PMID: 13716793

Full text

PDF
372

Images in this article

357Fig. 1.
on p.357
357Fig. 2.
on p.357
358Fig. 3.
on p.358
358Fig. 4.
on p.358
359Fig. 5.
on p.359
359Fig. 6.
on p.359
360Fig. 7.
on p.360
360Fig. 8.
on p.360
361Fig. 10.
on p.361
365Fig. 12., Fig. 13.
on p.365

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHLEY F. L., MOONEY S. A., EDWARDS J. W., GARCIA E. N., SYVERUD J. M., ALONSO-ARTIEDA M. Studies on mammalian homotransplants of skin. II. Tolerance induced with a pooled antigen of white blood cells and ribonucleic acid. Surg Forum. 1958;9:790–792. [PubMed] [Google Scholar]
  2. ASHLEY F. L., McNALL E. G., GARCIA E. N., SLOAN R. F., EDWARDS J. W. Studies on mammalian homotransplants of skin. III. An attempt to induce tolerance across the placenta in rats with RNA and DNA. Am J Surg. 1959 Aug;98(2):217–222. doi: 10.1016/0002-9610(59)90067-4. [DOI] [PubMed] [Google Scholar]
  3. BAKER R., GORDON R. Effect of total body irradiation on experimental renal transplantation. Surgery. 1955 May;37(5):820–822. [PubMed] [Google Scholar]
  4. BARNES D. W., ILBERY P. L., LOUTIT J. F. Avoidance of secondary disease in radiation chimaeras. Nature. 1958 Feb 15;181(4607):488–488. doi: 10.1038/181488a0. [DOI] [PubMed] [Google Scholar]
  5. BELL C. C., Jr, HAYNES B. W., Jr, HUME D. M., EGDAHL R. H. Clinical and experimental studies in fetal skin homografting. Surg Forum. 1960;10:857–860. [PubMed] [Google Scholar]
  6. BILLINGHAM R. E., BRENT L. A simple method for inducing tolerance of skin homografts in mice. Transplant Bull. 1957 Apr;4(2):67–71. [PubMed] [Google Scholar]
  7. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Actively acquired tolerance of foreign cells. Nature. 1953 Oct 3;172(4379):603–606. doi: 10.1038/172603a0. [DOI] [PubMed] [Google Scholar]
  8. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Extraction of antigens causing transplantation immunity. Transplant Bull. 1958 Oct;5(4):377–381. doi: 10.1097/00006534-195810000-00034. [DOI] [PubMed] [Google Scholar]
  9. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. The antigenic stimulus in transplantation immunity. Nature. 1956 Sep 8;178(4532):514–519. doi: 10.1038/178514a0. [DOI] [PubMed] [Google Scholar]
  10. BILLINGHAM R. E. Reactions of grafts against their hosts. Science. 1959 Oct 16;130(3381):947–953. doi: 10.1126/science.130.3381.947. [DOI] [PubMed] [Google Scholar]
  11. BROCADES ZAALBERG A., VOS O., BEKKUM VAN D. W. Surviving rat skin grafts in mice. Nature. 1957 Aug 3;180(4579):238–239. doi: 10.1038/180238b0. [DOI] [PubMed] [Google Scholar]
  12. CHANDLER G. N., WRIGHT V. Deleterious effect of intra-articular hydrocortisone. Lancet. 1958 Sep 27;2(7048):661–663. doi: 10.1016/s0140-6736(58)92262-1. [DOI] [PubMed] [Google Scholar]
  13. COCK A. G., SIMONSEN M. Immunological attack on newborn chickens by injected adult cells. Immunology. 1958 Apr;1(2):103–110. [PMC free article] [PubMed] [Google Scholar]
  14. COLE L. J., FISHLER M. C., ELLIS M. E., BOND V. P. Protection of mice against x-irradiation by spleen homogenates administered after exposure. Proc Soc Exp Biol Med. 1952 May;80(1):112–117. doi: 10.3181/00379727-80-19540. [DOI] [PubMed] [Google Scholar]
  15. COLE L. J., HABERMEYER J. G., BOND V. P. Recovery from acute radiation injury in mice following administration of rat bone marrow. J Natl Cancer Inst. 1955 Aug;16(1):1–9. [PubMed] [Google Scholar]
  16. CONGDON C. C., LORENZ E. Humoral factor in irradiation protection: modification of lethal irradiation injury in mice by injection of rat bone marrow. Am J Physiol. 1954 Feb;176(2):297–300. doi: 10.1152/ajplegacy.1954.176.2.297. [DOI] [PubMed] [Google Scholar]
  17. CONGDON C. C., URSO I. S. Homologous bone marrow in the treatment of radiation injury in mice. Am J Pathol. 1957 Jul-Aug;33(4):749–767. [PMC free article] [PubMed] [Google Scholar]
  18. DEMPSTER W. J. Kidney homotransplantation. Br J Surg. 1953 Mar;40(163):447–465. doi: 10.1002/bjs.18004016309. [DOI] [PubMed] [Google Scholar]
  19. DUPLAN J. F. Restauration des radiolésions par le foie foetal: influence de l'àge du donneur et du nombre de cellules injectées. C R Seances Soc Biol Fil. 1956 Sep 26;150(5):949–951. [PubMed] [Google Scholar]
  20. EGDAHL R. H., HUME D. M. Immunologic studies in renal homotransplantation. Surg Gynecol Obstet. 1956 Apr;102(4):450–462. [PubMed] [Google Scholar]
  21. FERREBEE J. W., BILLEN D., URSO I. M., LU W. C., THOMAS E. D., CONGDON C. C. Preservation of radiation recovery factor in frozen marrow. Blood. 1957 Dec;12(12):1096–1100. [PubMed] [Google Scholar]
  22. FORD C. E., HAMERTON J. L., BARNES D. W., LOUTIT J. F. Cytological identification of radiation-chimaeras. Nature. 1956 Mar 10;177(4506):452–454. doi: 10.1038/177452a0. [DOI] [PubMed] [Google Scholar]
  23. HAHN P. F., HOLT W. S., Jr, DANLEY D. A., MOOTRY P. J. Effects of protein deficiency and massive internal irradiation of the reticuloendothelial system on antibody reactions in kidney homotransplantation. Ann N Y Acad Sci. 1958 Oct 7;73(3):745–752. doi: 10.1111/j.1749-6632.1959.tb40851.x. [DOI] [PubMed] [Google Scholar]
  24. HASKOVA V., HRUBESOVA M. Part played by deoxyribonucleic acid in transplantation immunity. Nature. 1958 Jul 5;182(4627):61–62. doi: 10.1038/182061a0. [DOI] [PubMed] [Google Scholar]
  25. HOBSON D., PORTER K. A., WHITBY J. L. The immunological response of marrow-treated x-irradiated rabbits to bovine gamma-globulin. Br J Exp Pathol. 1959 Feb;40(1):15–24. [PMC free article] [PubMed] [Google Scholar]
  26. HUME D. M., MERRILL J. P., MILLER B. F., THORN G. W. Experiences with renal homotransplantation in the human: report of nine cases. J Clin Invest. 1955 Feb;34(2):327–382. doi: 10.1172/JCI103085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. ILBERY P. L., KOLLER P. C., LOUTIT J. F. Immunological characteristics of radiation chimaeras. J Natl Cancer Inst. 1958 Jun;20(6):1051–1089. doi: 10.1093/jnci/20.6.1051. [DOI] [PubMed] [Google Scholar]
  28. JACOBSON L. O. Evidence for a humoral factor (or factors) concerned in recovery from radiation injury: a review. Cancer Res. 1952 May;12(5):315–325. [PubMed] [Google Scholar]
  29. JACOBSON L. O., SIMMONS E. L., MARKS E. K., ELDREDGE J. H. Recovery from radiation injury. Science. 1951 May 4;113(2940):510–511. doi: 10.1126/science.113.2940.510. [DOI] [PubMed] [Google Scholar]
  30. LACASSAGNE A., DUPLAN J. F., BUUHOI N. P. Some new experiments on protection against whole-body irradiation. J Natl Cancer Inst. 1955 Feb;15(4):915–921. [PubMed] [Google Scholar]
  31. LAWRENCE H. S., RAPAPORT F. T., CONVERSE J. M., TILLETT W. S. Transfer of delayed hypersensitivity to skin homografts with leukocyte extracts in man. J Clin Invest. 1960 Jan;39:185–198. doi: 10.1172/JCI104018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. LEVINSON M. E., NECHELES H. Successful prolongation of survival of skin homografts. Plast Reconstr Surg (1946) 1956 Mar;17(3):218–219. doi: 10.1097/00006534-195603000-00005. [DOI] [PubMed] [Google Scholar]
  33. LORENZ E., UPHOFF D., REID T. R., SHELTON E. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst. 1951 Aug;12(1):197–201. [PubMed] [Google Scholar]
  34. MAIN J. M., PREHN R. T. Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow. J Natl Cancer Inst. 1955 Feb;15(4):1023–1029. [PubMed] [Google Scholar]
  35. MAKINODAN T. Circulating rat cells in lethally irradiated mice protected with rat bone marrow. Proc Soc Exp Biol Med. 1956 May;92(1):174–179. doi: 10.3181/00379727-92-22421. [DOI] [PubMed] [Google Scholar]
  36. MAKINODAN T. Fate of injected rat bone marrow cells in irradiated mice. J Cell Physiol Suppl. 1957 Dec;50(Suppl 1):157–161. doi: 10.1002/jcp.1030500411. [DOI] [PubMed] [Google Scholar]
  37. MAKINODAN T., GENGOZIAN N., SHEKARCHI I. C. Relative effects of splenic and bone-marrow cells on lethally irradiated mice. J Natl Cancer Inst. 1958 Mar;20(3):591–600. [PubMed] [Google Scholar]
  38. MANNICK J. A., LOCHTE H. L., Jr, ASHLEY C. A., THOMAS E. D., FERREBEE J. W. A functioning kidney homotransplant in the dog. Surgery. 1959 Oct;46:821–828. [PubMed] [Google Scholar]
  39. MANNICK J. A., POWERS J. H., MITHOEFER J., FERREBEE J. W. Renal transplantation in azotemic dogs. Surgery. 1960 Feb;47:340–345. [PubMed] [Google Scholar]
  40. MARTINEZ C., SMITH J. M., SHAPIRO F., GOOD R. A. Transfer of acquired immunological tolerance of skin homografts in mice joined in parabiosis. Proc Soc Exp Biol Med. 1959 Nov;102:413–417. doi: 10.3181/00379727-102-25268. [DOI] [PubMed] [Google Scholar]
  41. MITCHELL R. M. Attempts to induce tolerance of renal homografts in sheep by intraembryonic injection of splenic cells. Transplant Bull. 1959 Oct;6:424–426. doi: 10.1097/00006534-195910000-00038. [DOI] [PubMed] [Google Scholar]
  42. MITCHISON N. A. Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer. J Exp Med. 1955 Aug 1;102(2):157–177. doi: 10.1084/jem.102.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. MITCHISON N. A. The colonisation of irradiated tissue by transplanted spleen cells. Br J Exp Pathol. 1956 Jun;37(3):239–247. [PMC free article] [PubMed] [Google Scholar]
  44. MURRAY G., HOLDEN R. Transplantation of kidneys, experimentally and in human cases. Am J Surg. 1954 Apr;87(4):508–515. doi: 10.1016/0002-9610(54)90411-0. [DOI] [PubMed] [Google Scholar]
  45. NOSSAL G. J., LARKIN L. Failure to induce immunological tolerance during recovery from irradiation. Nature. 1958 Nov 22;182(4647):1447–1448. doi: 10.1038/1821447a0. [DOI] [PubMed] [Google Scholar]
  46. Owen R. D. IMMUNOGENETIC CONSEQUENCES OF VASCULAR ANASTOMOSES BETWEEN BOVINE TWINS. Science. 1945 Oct 19;102(2651):400–401. doi: 10.1126/science.102.2651.400. [DOI] [PubMed] [Google Scholar]
  47. PERSKY L., JAFFE S., HUBAY C. A. Renal homotransplantation to portal circulation. J Urol. 1959 Apr;81(4):506–508. doi: 10.1016/S0022-5347(17)66054-3. [DOI] [PubMed] [Google Scholar]
  48. PORTER K. A., COUCH N. P. Marrow treatment of irradiated dogs. Br J Exp Pathol. 1959 Feb;40(1):52–56. [PMC free article] [PubMed] [Google Scholar]
  49. PORTER K. A. Immune haemolysis in rabbit radiation-chimaeras. Br J Exp Pathol. 1960 Feb;41:72–80. [PMC free article] [PubMed] [Google Scholar]
  50. PORTER K. A., MOSELEY R. Effect of new-born rabbit and mouse liver suspensions on x-irradiated rabbits. Br J Exp Pathol. 1958 Apr;39(2):128–132. [PMC free article] [PubMed] [Google Scholar]
  51. PORTER K. A., MURRAY J. E. Homologous marrow transplantation in rabbits after triethylenethiophosphoramide. AMA Arch Surg. 1958 Jun;76(6):908–911. doi: 10.1001/archsurg.1958.01280240066010. [DOI] [PubMed] [Google Scholar]
  52. PORTER K. A., MURRAY J. E. Long-term study of x-irradiated rabbits with bone-marrow homotransplants. J Natl Cancer Inst. 1958 Jan;20(1):189–205. [PubMed] [Google Scholar]
  53. PUZA A., GOMBOS A. Acquired tolerance of skin homografts in dogs. Transplant Bull. 1958 Jan;5(1):30–32. doi: 10.1097/00007890-195801000-00016. [DOI] [PubMed] [Google Scholar]
  54. SIMONSEN M. The impact on the developing embryo and newborn animal of adult homologous cells. Acta Pathol Microbiol Scand. 1957;40(6):480–500. [PubMed] [Google Scholar]
  55. SISKIND G. W., THOMAS L. Studies on the runting syndrome in newborn mice. J Exp Med. 1959 Oct 1;110:511–523. doi: 10.1084/jem.110.4.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. STETSON C. A., Jr, DEMOPOULOS R. Reactions of skin homografts with specific immune sera. Ann N Y Acad Sci. 1958 Oct 7;73(3):687–692. doi: 10.1111/j.1749-6632.1959.tb40845.x. [DOI] [PubMed] [Google Scholar]
  57. TERASAKI P. I., CANNON J. A., LONGMIRE W. P., Jr Antibody repose to homografts. I. Technic of lymphoagglutination and detection of lymphoagglutining upon spleen injection. Proc Soc Exp Biol Med. 1959 Nov;102:280–285. doi: 10.3181/00379727-102-25220. [DOI] [PubMed] [Google Scholar]
  58. TERASAKI P. I., CANNON J. A., LONGMIRE W. P., Jr Time-lapse cinematography studies of the in vitro action of serum from homografted animals. Surg Forum. 1960;10:865–868. [PubMed] [Google Scholar]
  59. THOMAS E. D., ASHLEY C. A., LOCHTE H. L., Jr, JARETZKI A., 3rd, SAHLER O. D., FERREBEE J. W. Homografts of bone marrow in dogs after lethal total-body radiation. Blood. 1959 Jun;14(6):720–736. [PubMed] [Google Scholar]
  60. TOOLAN H. W. Studies of adult and embryonic skin homografts on conditioned or normal rabbits, with emphasis on the possible role of the ground substance. Ann N Y Acad Sci. 1958 Oct 7;73(3):546–560. doi: 10.1111/j.1749-6632.1959.tb40831.x. [DOI] [PubMed] [Google Scholar]
  61. TRENTIN J. J. Induced tolerance and homologous disease in x-irradiated mice protected with homologous bone marrow. Proc Soc Exp Biol Med. 1957 Oct;96(1):139–144. doi: 10.3181/00379727-96-23414. [DOI] [PubMed] [Google Scholar]
  62. TRENTIN J. J. Mortality and skin transplantability in x-irradiated mice receiving isologous, homologous or heterologous bone marrow. Proc Soc Exp Biol Med. 1956 Aug-Sep;92(4):688–693. doi: 10.3181/00379727-92-22582. [DOI] [PubMed] [Google Scholar]
  63. TRENTIN J. J. The immunological basis for induced tolerance to skin homografts in irradiated mice receiving bone marrow transfusions. Transplant Bull. 1957 Apr;4(2):74–76. [PubMed] [Google Scholar]
  64. UPHOFF D. E. Alteration of homograft reaction by A-methopterin in lethally irradiated mice treated with homologous marrow. Proc Soc Exp Biol Med. 1958 Dec;99(3):651–653. doi: 10.3181/00379727-99-24450. [DOI] [PubMed] [Google Scholar]
  65. UPHOFF D. E. Perclusion of secondary phase of irradiation syndrome by inoculation of fetal hematopoietic tissue following lethal total-body x-irradiation. J Natl Cancer Inst. 1958 Mar;20(3):625–632. [PubMed] [Google Scholar]
  66. URSO I. S., CONGDON C. C., OWEN R. D. Effect of foreign fetal and newborn blood-forming tissues on survival of lethally irradiated mice. Proc Soc Exp Biol Med. 1959 Feb;100(2):395–399. doi: 10.3181/00379727-100-24640. [DOI] [PubMed] [Google Scholar]
  67. VAN BEKKUM D. W., VOS O. Immunological aspects of homo- and heterologous bone marrow transplantation in irradiated animals. J Cell Physiol Suppl. 1957 Dec;50(Suppl 1):139–156. doi: 10.1002/jcp.1030500410. [DOI] [PubMed] [Google Scholar]
  68. WILSON R. E., DEALY J. B., Jr, SADOWSKY N. L., CORSON J. M., MURRAY J. E. Transplantation of homologous bone marrow and skin from common multiple donors following total body irradiation. Surgery. 1959 Jul;46(1):261–287. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES