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. 1995 Dec;85(12):1678–1683. doi: 10.2105/ajph.85.12.1678

Fluoride exposure and childhood osteosarcoma: a case-control study.

K H Gelberg 1, E F Fitzgerald 1, S A Hwang 1, R Dubrow 1
PMCID: PMC1615731  PMID: 7503344

Abstract

OBJECTIVES. This study tests the hypothesis that fluoride exposure in a nonoccupational setting is a risk factor for childhood osteosarcoma. METHODS. A population-based case-control study was conducted among residents of New York State, excluding New York City. Case subjects (n = 130) were diagnosed with osteosarcoma between 1978 and 1988, at age 24 years or younger. Control subjects were matched to case subjects on year of birth and sex. Exposure information was obtained by a telephone interview with the subject, parent, or both. RESULTS. Based on the parents' responses, total lifetime fluoride exposure was not significantly associated with osteosarcoma among all subjects combined or among females. However, a significant protective trend was observed among males. Protective trends were observed for fluoridated toothpaste, fluoride tablets, and dental fluoride treatments among all subjects and among males. Based on the subjects' responses, no significant associations between fluoride exposure and osteosarcoma were observed. CONCLUSIONS. Fluoride exposure does not increase the risk of osteosarcoma and may be protective in males. The protective effect may not be directly due to fluoride exposure but to other factors associated with good dental hygiene. There is also biologic plausibility for a protective effect.

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Selected References

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  1. Benedict W. F., Fung Y. K., Murphree A. L. The gene responsible for the development of retinoblastoma and osteosarcoma. Cancer. 1988 Oct 15;62(8 Suppl):1691–1694. doi: 10.1002/1097-0142(19881015)62:1+<1691::aid-cncr2820621306>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  2. Berry M. P., Jenkin R. D., Fornasier V. L., Rideout D. F. Osteosarcoma at the site of previous fracture. A case report. J Bone Joint Surg Am. 1980 Oct;62(7):1216–1218. [PubMed] [Google Scholar]
  3. Fraumeni J. F., Jr Stature and malignant tumors of bone in childhood and adolescence. Cancer. 1967 Jun;20(6):967–973. doi: 10.1002/1097-0142(196706)20:6<967::aid-cncr2820200606>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  4. Freni S. C., Gaylor D. W. International trends in the incidence of bone cancer are not related to drinking water fluoridation. Cancer. 1992 Aug 1;70(3):611–618. doi: 10.1002/1097-0142(19920801)70:3<611::aid-cncr2820700312>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  5. Gruber H. E., Baylink D. J. The effects of fluoride on bone. Clin Orthop Relat Res. 1991 Jun;(267):264–277. [PubMed] [Google Scholar]
  6. Heifetz S. B., Horowitz H. S. Amounts of fluoride in self-administered dental products: safety considerations for children. Pediatrics. 1986 Jun;77(6):876–882. [PubMed] [Google Scholar]
  7. Homa D. M., Sowers M. R., Schwartz A. G. Incidence and survival rates of children and young adults with osteogenic sarcoma. Cancer. 1991 Apr 15;67(8):2219–2223. doi: 10.1002/1097-0142(19910415)67:8<2219::aid-cncr2820670837>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  8. Hoover R. N., McKay F. W., Fraumeni J. F., Jr Fluoridated drinking water and the occurrence of cancer. J Natl Cancer Inst. 1976 Oct;57(4):757–768. doi: 10.1093/jnci/57.4.757. [DOI] [PubMed] [Google Scholar]
  9. Hrudey S. E., Soskolne C. L., Berkel J., Fincham S. Drinking water fluoridation and osteosarcoma. Can J Public Health. 1990 Nov-Dec;81(6):415–416. [PubMed] [Google Scholar]
  10. Mahoney M. C., Nasca P. C., Burnett W. S., Melius J. M. Bone cancer incidence rates in New York State: time trends and fluoridated drinking water. Am J Public Health. 1991 Apr;81(4):475–479. doi: 10.2105/ajph.81.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Malkin D., Li F. P., Strong L. C., Fraumeni J. F., Jr, Nelson C. E., Kim D. H., Kassel J., Gryka M. A., Bischoff F. Z., Tainsky M. A. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990 Nov 30;250(4985):1233–1238. doi: 10.1126/science.1978757. [DOI] [PubMed] [Google Scholar]
  12. Marcove R. C., Miké V., Hajek J. V., Levin A. G., Hutter R. V. Osteogenic sarcoma under the age of twenty-one. A review of one hundred and forty-five operative cases. J Bone Joint Surg Am. 1970 Apr;52(3):411–423. [PubMed] [Google Scholar]
  13. Martin G. R., Brown K. S., Matheson D. W., Lebowitz H., Singer L., Ophaug R. Lack of cytogenetic effects in mice or mutations in Salmonella receiving sodium fluoride. Mutat Res. 1979 Feb;66(2):159–167. doi: 10.1016/0165-1218(79)90061-2. [DOI] [PubMed] [Google Scholar]
  14. Maurer J. K., Cheng M. C., Boysen B. G., Anderson R. L. Two-year carcinogenicity study of sodium fluoride in rats. J Natl Cancer Inst. 1990 Jul 4;82(13):1118–1126. doi: 10.1093/jnci/82.13.1118. [DOI] [PubMed] [Google Scholar]
  15. McGuire S. M., Vanable E. D., McGuire M. H., Buckwalter J. A., Douglass C. W. Is there a link between fluoridated water and osteosarcoma? J Am Dent Assoc. 1991 Apr;122(4):38–45. doi: 10.14219/jada.archive.1991.0149. [DOI] [PubMed] [Google Scholar]
  16. Miller R. W. Etiology of childhood bone cancer: epidemiologic observations. Recent Results Cancer Res. 1976;(54):50–62. doi: 10.1007/978-3-642-80997-2_5. [DOI] [PubMed] [Google Scholar]
  17. PRICE C. H. Osteogenic sarcoma; an analysis of the age and sex incidence. Br J Cancer. 1955 Dec;9(4):558–574. doi: 10.1038/bjc.1955.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Parkins F. M. Retention of fluoride with chewable tablets and a mouthrinse. J Dent Res. 1972 Sep-Oct;51(5):1346–1349. doi: 10.1177/00220345720510051601. [DOI] [PubMed] [Google Scholar]
  19. Polednak A. P. Primary bone cancer incidence in black and white residents of New York State. Cancer. 1985 Jun 15;55(12):2883–2888. doi: 10.1002/1097-0142(19850615)55:12<2883::aid-cncr2820551231>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  20. Rowland R. E., Stehney A. F., Lucas H. F. Dose-response relationships for radium-induced bone sarcomas. Health Phys. 1983;44 (Suppl 1):15–31. doi: 10.1097/00004032-198306001-00001. [DOI] [PubMed] [Google Scholar]
  21. Schulz E. E., Libanati C. R., Farley S. M., Kirk G. A., Baylink D. J. Skeletal scintigraphic changes in osteoporosis treated with sodium fluoride: concise communication. J Nucl Med. 1984 Jun;25(6):651–655. [PubMed] [Google Scholar]
  22. Smith G. E. Is fluoride a mutagen? Sci Total Environ. 1988 Jan;68:79–96. doi: 10.1016/0048-9697(88)90363-4. [DOI] [PubMed] [Google Scholar]
  23. Tsutsui T., Suzuki N., Ohmori M. Sodium fluoride-induced morphological and neoplastic transformation, chromosome aberrations, sister chromatid exchanges, and unscheduled DNA synthesis in cultured syrian hamster embryo cells. Cancer Res. 1984 Mar;44(3):938–941. [PubMed] [Google Scholar]

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