Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1980 Apr;55(4):285–287. doi: 10.1136/adc.55.4.285

Serum 25-hydroxy-vitamin D levels in malnourished children with rickets.

N Raghuramulu, V Reddy
PMCID: PMC1626835  PMID: 6774669

Abstract

Serum levels of calcium, phosphorus, alkaline phosphatase, and 25 hydroxy-vitamin D (25-OH-D3) were measured in normal and malnourished children with and without rickets. Children with rickets had clinical, biochemical, and x-ray evidence of the disease; most of them were malnourished. 25-OH-D3 levels were lower than in normal children. After treatment with vitamin D their condition improved. 25-OH-D3 levels were also found to be reduced in malnourished children without rickets. These studies show that rickets is common in malnourished children. Inadequate exposure to sunlight appears to be the factor mainly responsible for the high incidence of the disease. In addition, malnutrition perhaps contributes to the development of rickets.

Full text

PDF
287

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banik N. D., Nayar S., Krishna R., Raj L. A study of epidemiologic basis of malnutrition in pre-school children in slum areas in Delhi. Indian Pediatr. 1973 Jan;10(1):19–25. [PubMed] [Google Scholar]
  2. Belsey R. E., DeLuca H. F., Potts J. T., Jr A rapid assay for 25-OH-vitamin D3 without preparative chromatography. J Clin Endocrinol Metab. 1974 Jun;38(6):1046–1051. doi: 10.1210/jcem-38-6-1046. [DOI] [PubMed] [Google Scholar]
  3. Bhaskaram C., Reddy V. Role of dietary phytate in the aetiology of nutritional rickets. Indian J Med Res. 1979 Feb;69:265–270. [PubMed] [Google Scholar]
  4. Ghosh S., Bhardawaj O. P., Saini L., Varma K. P. A survey of rickets. Indian Pediatr. 1966 Jan;3(1):9–14. [PubMed] [Google Scholar]
  5. Goel K. M., Sweet E. M., Logan R. W., Warren J. M., Arneil G. C., Shanks R. A. Florid and subclinical rickets among immigrant children in Glasgow. Lancet. 1976 May 29;1(7970):1141–1145. doi: 10.1016/s0140-6736(76)91538-5. [DOI] [PubMed] [Google Scholar]
  6. Gupta M., Agarwal K. N. Nutritional status of pre-school children. II. Clinical assessment of nutritional deficiencies. Indian Pediatr. 1972 Aug;9(8):450–453. [PubMed] [Google Scholar]
  7. Mahajan C. M., Bidwai P. S. Total anomalous pulmonary venous connection with valvular pulmonic stenosis. (A case report). Indian Pediatr. 1971 Mar;8(3):95–97. [PubMed] [Google Scholar]
  8. Manchanda S. S., Lal H. The challenge of rickets in Punjab. Indian J Pediatr. 1972 Feb;39(289):52–57. doi: 10.1007/BF02799407. [DOI] [PubMed] [Google Scholar]
  9. Preece M. A., TomlinsonS, Ribot C. A., Pietrek J., Korn H. T., Davies D. M., Ford J. A., Dunnigan M. G., O'Riordan J. L. Studies of vitamin D deficiency in man. Q J Med. 1975 Oct;44(176):575–589. [PubMed] [Google Scholar]
  10. Rao D. H., Satyanarayana K., Sastry J. G. Growth pattern of well-to-do Hyderabad pre-school children. Indian J Med Res. 1976 May;64(5):629–638. [PubMed] [Google Scholar]
  11. Rao N. P., Singh D., Swaminathan M. C. Nutritional status of pre-school children of rural communities near Hyderabad city. Indian J Med Res. 1969 Nov;57(11):2132–2146. [PubMed] [Google Scholar]
  12. Reddy V., Srikantia S. G. Serum alkaline phosphatase in malnourished children with rickets. J Pediatr. 1967 Oct;71(4):595–597. doi: 10.1016/s0022-3476(67)80117-3. [DOI] [PubMed] [Google Scholar]
  13. Salimpour R. Rickets in Tehran. Study of 200 cases. Arch Dis Child. 1975 Jan;50(1):63–66. doi: 10.1136/adc.50.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stamp T. C. Factors in human vitamin D nutrition and in the production and cure of classical rickets. Proc Nutr Soc. 1975 Sep;34(2):119–130. doi: 10.1079/pns19750022. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES