Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1980 Sep;55(9):673–677. doi: 10.1136/adc.55.9.673

Plasma motilin, gastrin, and enteroglucagon and feeding in the human newborn.

A Lucas, T E Adrian, N Christofides, S R Bloom, A Aynsley-Green
PMCID: PMC1627011  PMID: 7436530

Abstract

Plasma concentrations of motilin, gastrin, and enteroglucagon were measured in cord blood and during the first 24 days of life before feeding in 45 term and 63 preterm, healthy infants. Levels of these hormones rose steeply after birth, reaching concentrations that were much higher than those in fasting adults. These increases in hormone concentration were not present in a group of 10 preterm infants who had received only intravaenous dextrose from birth because of hyaline membrane disease. Our findings suggest that early enteral feeding may trigger the postnatal increase in plasma concentrations of gut hormones and that this could play an important role in the physiologaical adaptations to extrauterine nutrition.

Full text

PDF
675

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aynsley-Green A., Bloom S. R., Williamson D. H., Turner R. C. Endocrine and metabolic response in the human newborn to first feed of breast milk. Arch Dis Child. 1977 Apr;52(4):291–295. doi: 10.1136/adc.52.4.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Besterman H. S., Bloom S. R., Sarson D. L., Blackburn A. M., Johnston D. I., Patel H. R., Stewart J. S., Modigliani R., Guerin S., Mallinson C. N. Gut-hormone profile in coeliac disease. Lancet. 1978 Apr 15;1(8068):785–788. doi: 10.1016/s0140-6736(78)92994-x. [DOI] [PubMed] [Google Scholar]
  3. Bloom S. R., Mitznegg P., Bryant M. G. Measurement of human plasma motilin. Scand J Gastroenterol Suppl. 1976;39:47–52. [PubMed] [Google Scholar]
  4. Brown J. C., Mutt V., Dryburgh J. R. The further purification of motilin, a gastric motor activity stimulating polypeptide from the mucosa of the small intestine of hogs. Can J Physiol Pharmacol. 1971 May;49(5):399–405. doi: 10.1139/y71-047. [DOI] [PubMed] [Google Scholar]
  5. EBERS D. W., GIBBS G. E., SMITH D. I. Gastric acidity on the first day of life. Pediatrics. 1956 Nov;18(5):800–802. [PubMed] [Google Scholar]
  6. Euler A. R., Byrne W. J., Cousins L. M., Ament M. E., Walsh J. H. Increased serum gastrin concentrations and gastric acid hyposecretion in the immediate newborn period. Gastroenterology. 1977 Jun;72(6):1271–1273. [PubMed] [Google Scholar]
  7. Gleeson M. H., Bloom S. R., Polak J. M., Henry K., Dowling R. H. Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut. 1971 Oct;12(10):773–782. doi: 10.1136/gut.12.10.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Harries J. T., Fraser A. J. The acidity of the gastric contents of premature babies during the first fourteen days of life. Biol Neonat. 1968;12(3):186–193. doi: 10.1159/000240105. [DOI] [PubMed] [Google Scholar]
  9. Johnson L. R., Guthrie P. D. Stimulation of DNA synthesis by big and little gastrin (G-34 and G-17). Gastroenterology. 1976 Oct;71(4):599–602. [PubMed] [Google Scholar]
  10. Johnson L. R. New aspects of the trophic action of gastrointestinal hormones. Gastroenterology. 1977 Apr;72(4 PT2):788–792. [PubMed] [Google Scholar]
  11. Johnson L. R. The trophic action of gastrointestinal hormones. Gastroenterology. 1976 Feb;70(2):278–288. [PubMed] [Google Scholar]
  12. Lucas A., Bloom S. R., Aynsley-Green A. Metabolic and endocrine events at the time of the first feed of human milk in preterm and term infants. Arch Dis Child. 1978 Sep;53(9):731–736. doi: 10.1136/adc.53.9.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mayston P. D., Barrowman J. A. The influence of chronic administration of pentagastrin on the rat pancreas. Q J Exp Physiol Cogn Med Sci. 1971 Apr;56(2):113–122. doi: 10.1113/expphysiol.1971.sp002105. [DOI] [PubMed] [Google Scholar]
  14. Pearse A. G., Polak J. M., Bloom S. R., Adams C., Dryburgh J. R., Brown J. C. Enterochromaffin cells of the mammalian small intestine as the source of motilin. Virchows Arch B Cell Pathol. 1974;16(2):111–120. doi: 10.1007/BF02894069. [DOI] [PubMed] [Google Scholar]
  15. Rogers I. M., Davidson D. C., Lawrence J., Ardill J., Buchanan K. D. Neonatal secretion of gastrin and glucagon. Arch Dis Child. 1974 Oct;49(10):796–801. doi: 10.1136/adc.49.10.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Russel R. C., Bloom S. R., Fielding L. P., Bryant M. G. Current problems in the measurement of gastrin release. A reproducible measure of physiological gastrin release. Postgrad Med J. 1976 Oct;52(612):645–650. doi: 10.1136/pgmj.52.612.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sann L., Chayvialle A. P., Bremond A., Lambert R. Serum gastrin level in early childhood. Arch Dis Child. 1975 Oct;50(10):782–785. doi: 10.1136/adc.50.10.782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stoddart R. W., Widdowson E. M. Changes in the organs of pigs in response to feeding for the first 24 h after birth. III. Fluorescence histochemistry of the carbohydrates of the intestine. Biol Neonate. 1976;29(1-2):18–27. doi: 10.1159/000240844. [DOI] [PubMed] [Google Scholar]
  19. Thomson J. P., Bloom S. R. Plasma enteroglucagon and plasma volume change after gastric surgery. Clin Sci Mol Med. 1976 Aug;51(2):177–183. doi: 10.1042/cs0510177. [DOI] [PubMed] [Google Scholar]
  20. von Berger L., Henrichs I., Raptis S., Heinze E., Jonatha W., Teller W. M., Pfeiffer E. F. Gastrin concentration in plasma of the neonate at birth and after the first feeding. Pediatrics. 1976 Aug;58(2):264–267. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES