Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1981 May;56(5):386–389. doi: 10.1136/adc.56.5.386

Disordered prolactin secretion in the obese child and adolescent.

E Cacciari, E Frejaville, A Balsamo, A Cicognani, P Pirazzoli, F Bernardi, F Zappulla
PMCID: PMC1627422  PMID: 6789779

Abstract

Thirty-eight obese (13 prepubertal, 25 pubertal) boys, and 17 obese (16 prepubertal, 11 pubertal) girls underwent a thyroid-releasing hormone test with assay of prolactin. Obese pre-pubertal boys had prolactin levels that were significantly below those of the control group both under basal conditions and after stimulus. In the obese pubertal boys the difference was significant only after stimulus. The pituitary prolactin reserve in obese pubertal girls was lower than that of the control group. We conclude that in children and adolescents obesity may induce a hypothalamo-pituitary disorder that affects prolactin secretion.

Full text

PDF
386

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apter D., Pakarinen A., Vihko R. Serum prolactin, FSH and LH during puberty in girls and boys. Acta Paediatr Scand. 1978 Jul;67(4):417–423. doi: 10.1111/j.1651-2227.1978.tb16348.x. [DOI] [PubMed] [Google Scholar]
  2. Aubert M. L., Grumbach M. M., Kaplan S. L. Heterologous radioimmunoassay for plasma human prolactin (hPRL); values in normal subjects, puberty, pregnancy and in pituitary disorders. Acta Endocrinol (Copenh) 1974 Nov;77(3):460–476. doi: 10.1530/acta.0.0770460. [DOI] [PubMed] [Google Scholar]
  3. Cacciari E., Cicognani A., Pirazzoli P., Tassoni P., Zappulla F., Salardi S., Bernardi F. Relationships among the secretion of ACTH, GH, and cortisol during the insulin-induced hypoglycemia test in the normal and obese child. J Clin Endocrinol Metab. 1975 May;40(5):802–806. doi: 10.1210/jcem-40-5-802. [DOI] [PubMed] [Google Scholar]
  4. Cacciari E., Cicognani A., Pirazzoli P., Zappulla F., Tassoni P., Bernardi F., Salardi S., Mazzanti L. Effect of obesity on the hypothalamo-pituitary-gonadal function in childhood. Acta Paediatr Scand. 1977 May;66(3):345–348. doi: 10.1111/j.1651-2227.1977.tb07905.x. [DOI] [PubMed] [Google Scholar]
  5. Ehara Y., Yen S. S., Siler T. M. Serum prolactin levels during puberty. Am J Obstet Gynecol. 1975 Apr 1;121(7):995–997. doi: 10.1016/0002-9378(75)90925-4. [DOI] [PubMed] [Google Scholar]
  6. Kopelman P. G., White N., Pilkington T. R., Jeffcoate S. L. Impaired hypothalamic control of prolactin secretion in massive obesity. Lancet. 1979 Apr 7;1(8119):747–750. doi: 10.1016/s0140-6736(79)91206-6. [DOI] [PubMed] [Google Scholar]
  7. Larson B. A., Sinha Y. N., Vanderlaan W. P. Serum growth hormone and prolactin during and after the development of the obese-hyperglycemic syndrome in mice. Endocrinology. 1976 Jan;98(1):139–145. doi: 10.1210/endo-98-1-139. [DOI] [PubMed] [Google Scholar]
  8. Odell W. D., Wilber J. F., Paul W. E. Radioimmunoassay of thyrotropin in human serum. J Clin Endocrinol Metab. 1965 Sep;25(9):1179–1188. doi: 10.1210/jcem-25-9-1179. [DOI] [PubMed] [Google Scholar]
  9. Rubin R. T., Poland R. E., Tower B. B. Prolactin-related testosterone secretion in normal adult men. J Clin Endocrinol Metab. 1976 Jan;42(1):112–116. doi: 10.1210/jcem-42-1-112. [DOI] [PubMed] [Google Scholar]
  10. Sizonenko P. C. Endocrinology in preadolescents and adolescents. I. Hormonal changes during normal puberty. Am J Dis Child. 1978 Jul;132(7):704–712. doi: 10.1001/archpedi.1978.02120320064015. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES