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. 1981 May;56(5):342–344. doi: 10.1136/adc.56.5.342

Bronchodilator effects of clemastine, ipratropium, bromide, and salbutamol in preschool children with asthma.

R C Groggins, A D Milner, G M Stokes
PMCID: PMC1627441  PMID: 6455096

Abstract

The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHAMBERLAIN D. A., MUIR D. C., KENNEDY K. P. Atropine methonitrate and isoprenaline in bronchial asthma. Lancet. 1962 Nov 17;2(7264):1019–1021. doi: 10.1016/s0140-6736(62)92704-6. [DOI] [PubMed] [Google Scholar]
  2. Cogswell J. J. Forced oscillation technique for determination of resistance to breathing in children. Arch Dis Child. 1973 Apr;48(4):259–266. doi: 10.1136/adc.48.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Groggins R. C., Lenney W., Milner A. D., Stokes G. M. Efficacy of orally administered salbutamol and theophylline in pre-schoolchildren with asthma. Arch Dis Child. 1980 Mar;55(3):204–206. doi: 10.1136/adc.55.3.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Groggins R. C., Milner A. D., Stokes G. M. The bronchodilator effects of chlorpheniramine in childhood asthma. Br J Dis Chest. 1979 Jul;73(3):297–301. [PubMed] [Google Scholar]
  5. Hensley M. J., O'Cain C. F., McFadden E. R., Jr, Ingram R. H., Jr Distribution of bronchodilatation in normal subjects: beta agonist versus atropine. J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov;45(5):778–782. doi: 10.1152/jappl.1978.45.5.778. [DOI] [PubMed] [Google Scholar]
  6. Lenney W., Milner A. D. At what age do bronchodilator drugs work? Arch Dis Child. 1978 Jul;53(7):532–535. doi: 10.1136/adc.53.7.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lenney W., Milner A. D. Recurrent wheezing in the preschool child. Arch Dis Child. 1978 Jun;53(6):468–473. doi: 10.1136/adc.53.6.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lin M. T., Lee-Hong E., Collins-Williams C. A clinical trial of the bronchodilator effect of Sch 1000 aerosol in asthmatic children. Ann Allergy. 1978 May;40(5):326–332. [PubMed] [Google Scholar]
  9. Milner A. D., Ingram D. Peak expiratory flow rates in children under 5 years of age. Arch Dis Child. 1970 Dec;45(244):780–782. doi: 10.1136/adc.45.244.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nogrady S. G., Hartley J. P., Handslip P. D., Hurst N. P. Bronchodilatation after inhalation of the antihistamine clemastine. Thorax. 1978 Aug;33(4):479–482. doi: 10.1136/thx.33.4.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pierce R. J., Allen C. J., Campbell A. H. A comparative study of atropine methonitrate, salbutamol, and their combination in airways obstruction. Thorax. 1979 Feb;34(1):45–50. doi: 10.1136/thx.34.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child. 1966 Dec;41(220):613–635. doi: 10.1136/adc.41.220.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Thomson N. C., Patel K. R., Kerr J. W. Sodium cromoglycate and ipratropium bromide in exercise-induced asthma. Thorax. 1978 Dec;33(6):694–699. doi: 10.1136/thx.33.6.694. [DOI] [PMC free article] [PubMed] [Google Scholar]

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