Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1981 Dec;56(12):939–942. doi: 10.1136/adc.56.12.939

Eczema and atopy in early childhood: low IgA plasma cell counts in the jejunal mucosa.

K S Sloper, C G Brook, D Kingston, J R Pearson, M Shiner
PMCID: PMC1627507  PMID: 7332341

Abstract

Twenty-one children aged between 2 and 54 months, 14 with eczema and 7 with allergies in first-degree relatives, were referred for diagnostic jejunal mucosal biopsy for a variety of symptoms. A partial villous atrophy was found in 19 of the 21 biopsies obtained; the other 2 were normal. We report a highly significant (P less than 0.0001) lower IgA cell count in biopsies with partial villous atrophy compared with the results of our previous study of IgA and IgM plasma cells in the mucosal biopsies in children without eczema or a history of atopy matched for age and histological appearances. The IgM cell count was also lower.

Full text

PDF
940

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DONIACH I., SHINER M. Duodenal and jejunal biopsies. II. Histology. Gastroenterology. 1957 Jul;33(1):71–86. [PubMed] [Google Scholar]
  2. Kaufman H. S., Hobbs J. R. Immunoglobulin deficiencies in an atopic population. Lancet. 1970 Nov 21;2(7682):1061–1063. doi: 10.1016/s0140-6736(70)90288-6. [DOI] [PubMed] [Google Scholar]
  3. Maffei H. V., Kingston D., Hill I. D., Shiner M. Histopathologic changes and the immune response within the jejunal mucosa in infants and children. Pediatr Res. 1979 Jun;13(6):733–736. doi: 10.1203/00006450-197906000-00002. [DOI] [PubMed] [Google Scholar]
  4. Orgel H. A., Hamburger R. N., Bazaral M., Gorrin H., Groshong T., Lenoir M., Miller J. R., Wallace W. Development of IgE and allergy in infancy. J Allergy Clin Immunol. 1975 Oct;56(4):296–307. doi: 10.1016/0091-6749(75)90104-9. [DOI] [PubMed] [Google Scholar]
  5. Penna F. J., Hill I. D., Kingston D., Robertson K., Slavin G., Shiner M. Jejunal mucosal morphometry in children with and without gut symptoms and in normal adults. J Clin Pathol. 1981 Apr;34(4):386–392. doi: 10.1136/jcp.34.4.386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Savilahti E. IgA deficiency in children. Immunoglobulin-containing cells in the intestinal mucosa, immunoglobulins in secretions and serum IgA levels. Clin Exp Immunol. 1973 Mar;13(3):395–406. [PMC free article] [PubMed] [Google Scholar]
  7. Soothill J. F., Stokes C. R., Turner M. W., Norman A. P., Taylor B. Predisposing factors and the development of reaginic allergy in infancy. Clin Allergy. 1976 Jul;6(4):305–319. doi: 10.1111/j.1365-2222.1976.tb01911.x. [DOI] [PubMed] [Google Scholar]
  8. Taylor B., Norman A. P., Orgel H. A., Stokes C. R., Turner M. W., Soothill J. F. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973 Jul 21;2(7821):111–113. doi: 10.1016/s0140-6736(73)93060-2. [DOI] [PubMed] [Google Scholar]
  9. Walker W. A. Antigen absorption from the small intestine and gastrointestinal disease. Pediatr Clin North Am. 1975 Nov;22(4):731–746. doi: 10.1016/s0031-3955(16)33204-7. [DOI] [PubMed] [Google Scholar]
  10. Walker W. A., Isselbacher K. J. Uptake and transport of macromolecules by the intestine. Possible role in clinical disorders. Gastroenterology. 1974 Sep;67(3):531–550. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES