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. 1983 Mar;58(3):190–194. doi: 10.1136/adc.58.3.190

Normal ranges of T4 screening values in low birthweight infants.

J H Kok, G Hart, E Endert, J G Koppe, J J de Vijlder
PMCID: PMC1627847  PMID: 6838250

Abstract

Thyroxine (T4) screening values in infants of low birthweight in relation to birthweight and gestational age are reported. There were 86 healthy infants of low birthweight (group 1), and 29 preterm infants with respiratory distress syndrome (group 2). All the group 2 infants and 36% of those in group 1 had a T4 screening value below the cut-off point (-2.1 SD). In group 1 there was a significant increase in T4 with birthweight at a given gestational age, as well as with gestational age at a given birthweight. In group 2 there was also a significant increase in T4 values in relation to birthweight and gestational age, but it could not be ascertained whether this increase existed at a given gestational age or birthweight. A statistical model giving normal ranges of T4 for both groups of infants is presented, which, if applied to low birthweight infants, makes it possible to estimate the effect of low birthweight on T4 screening values, provided the birthweight and gestational age are known. In this manner the sensitivity of screening for congenital hypothyroidism is enhanced and the recall rate reduced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernard B., Oddie T. H., Fisher D. A. Correlation between gestational age, weight, or ponderosity and serum thyroxine concentration at birth. J Pediatr. 1977 Aug;91(2):199–203. doi: 10.1016/s0022-3476(77)80812-3. [DOI] [PubMed] [Google Scholar]
  2. Chopra I. J. A radioimmunoassay for measurement of thyroxine in unextracted serum. J Clin Endocrinol Metab. 1972 Jun;34(6):938–947. doi: 10.1210/jcem-34-6-938. [DOI] [PubMed] [Google Scholar]
  3. Chopra I. J., Solomon D. H., Hepner G. W., Morgenstein A. A. Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses. Ann Intern Med. 1979 Jun;90(6):905–912. doi: 10.7326/0003-4819-90-6-905. [DOI] [PubMed] [Google Scholar]
  4. Cuestas R. A., Engel R. R. Thyroid function in preterm infants with respiratory distress syndrome. J Pediatr. 1979 Apr;94(4):643–646. doi: 10.1016/s0022-3476(79)80042-6. [DOI] [PubMed] [Google Scholar]
  5. Delange F., Dodion J., Wolter R., Bourdoux P., Dalhem A., Glinoer D., Ermans A. M. Transient hypothyroidism in the newborn infant. J Pediatr. 1978 Jun;92(6):974–976. doi: 10.1016/s0022-3476(78)80380-1. [DOI] [PubMed] [Google Scholar]
  6. Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
  7. Dussault J. H., Morissette J., Laberge C. Blood thyroxine concentration is lower in low-birth-weight infants. Clin Chem. 1979 Dec;25(12):2047–2049. [PubMed] [Google Scholar]
  8. Fisher D. A., Hobel C. J., Garza R., Pierce C. A. Thyroid function in the preterm fetus. Pediatrics. 1970 Aug;46(2):208–216. [PubMed] [Google Scholar]
  9. Hadeed A. J., Asay L. D., Klein A. H., Fisher D. A. Significance of transient postnatal hypothyroxinemia in premature infants with and without respiratory distress syndrome. Pediatrics. 1981 Oct;68(4):494–498. [PubMed] [Google Scholar]
  10. Klein A. H., Foley B., Foley T. P., MacDonald H. M., Fisher D. A. Thyroid function studies in cord blood from premature infants with and without RDS. J Pediatr. 1981 May;98(5):818–820. doi: 10.1016/s0022-3476(81)80856-6. [DOI] [PubMed] [Google Scholar]
  11. LaFranchi S. H., Murphey W. H., Foley T. P., Jr, Larsen P. R., Buist N. R. Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics. 1979 Feb;63(2):180–191. [PubMed] [Google Scholar]
  12. Mitchell M. L., Larsen P. R., Levy H. L., Bennett A. J., Madoff M. A. Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA. 1978 Jun 2;239(22):2348–2351. doi: 10.1001/jama.239.22.2348. [DOI] [PubMed] [Google Scholar]
  13. Odell W. D., Wilber J. F., Paul W. E. Radioimmunoassay of thyrotropin in human serum. J Clin Endocrinol Metab. 1965 Sep;25(9):1179–1188. doi: 10.1210/jcem-25-9-1179. [DOI] [PubMed] [Google Scholar]
  14. Redding R. A., Pereira C. Thyroid function in respiratory distress syndrome (RDS) of the newborn. Pediatrics. 1974 Oct;54(4):423–428. [PubMed] [Google Scholar]
  15. Schönberger W., Grimm W., Emmrich P., Gempp W. Reduction of mortality rate in premature infants by substitution of thyroid hormones. Eur J Pediatr. 1981 Feb;135(3):245–253. doi: 10.1007/BF00442098. [DOI] [PubMed] [Google Scholar]
  16. USHER R. The respiratory distress syndrome of prematurity. Clinical and therapeutic aspects. Pediatr Clin North Am. 1961 May;8:525–538. doi: 10.1016/s0031-3955(16)31125-7. [DOI] [PubMed] [Google Scholar]
  17. Uhrmann S., Marks K. H., Maisels M. J., Kulin H. E., Kaplan M., Utiger R. Frequency of transient hypothyroxinaemia in low birthweight infants. Potential pitfall for neonatal screening programmes. Arch Dis Child. 1981 Mar;56(3):214–217. doi: 10.1136/adc.56.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]

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