Abstract
Plasma 17-hydroxyprogesterone concentrations were determined in 47 preterm and term infants who were ill from a variety of causes. The results were compared with those in 53 healthy term infants. Mean plasma 17-hydroxyprogesterone values were appreciably higher in ill term and healthy preterm infants compared with healthy term infants, but the highest values were found in ill preterm infants. None of the infants had adrenal disease but some very ill infants had plasma 17-hydroxyprogesterone values approaching those seen in untreated infants with congenital adrenal hyperplasia. Interpretation of the results of plasma steroid measurements in newborn infants must take account of gestational age and the presence of stress related illness.
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- Barnes N. D., Atherden S. M. Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17-hydroxyprogesterone. Arch Dis Child. 1972 Feb;47(251):62–65. doi: 10.1136/adc.47.251.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bommen M., Brook C. G. Pseudohypoaldosteronism. Response to long-term treatment with indomethacin. Arch Dis Child. 1982 Sep;57(9):718–720. doi: 10.1136/adc.57.9.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forest M. G., Cathiard A. M. Ontogenic study of plasma 17alpha-hydroxyprogesterone in the human. I. Postnatal period: evidence for a transient ovarian activity in infancy. Pediatr Res. 1978 Jan;12(1):6–11. doi: 10.1203/00006450-197801000-00003. [DOI] [PubMed] [Google Scholar]
- Guignard J. P. Renal function in the newborn infant. Pediatr Clin North Am. 1982 Aug;29(4):777–790. doi: 10.1016/s0031-3955(16)34211-0. [DOI] [PubMed] [Google Scholar]
- Hughes I. A., Riad-Fahmy D., Griffiths K. Plasma 17OH-progesterone concentrations in newborn infants. Arch Dis Child. 1979 May;54(5):347–349. doi: 10.1136/adc.54.5.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kemp K. W., Nix A. B., Wilson D. W., Griffiths K. Internal quality control of radioimmunoassays. J Endocrinol. 1978 Feb;76(2):203–210. doi: 10.1677/joe.0.0760203. [DOI] [PubMed] [Google Scholar]
- Pang S., Hotchkiss J., Drash A. L., Levine L. S., New M. I. Microfilter paper method for 17 alpha-hydroxyprogesterone radioimmunoassay: its application for rapid screening for congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1977 Nov;45(5):1003–1008. doi: 10.1210/jcem-45-5-1003. [DOI] [PubMed] [Google Scholar]
- Pang S., Levine L. S., Chow D. M., Faiman C., New M. I. Serum androgen concentrations in neonates and young infants with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Clin Endocrinol (Oxf) 1979 Dec;11(6):575–584. doi: 10.1111/j.1365-2265.1979.tb03111.x. [DOI] [PubMed] [Google Scholar]
- Pang S., Murphey W., Levine L. S., Spence D. A., Leon A., LaFranchi S., Surve A. S., New M. I. A pilot newborn screening for congenital adrenal hyperplasia in Alaska. J Clin Endocrinol Metab. 1982 Sep;55(3):413–420. doi: 10.1210/jcem-55-3-413. [DOI] [PubMed] [Google Scholar]
- Sippell W. G., Dörr H. G., Bidlingmaier F., Knorr D. Plasma levels of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, cortisol, and cortisone during infancy and childhood. Pediatr Res. 1980 Jan;14(1):39–46. doi: 10.1203/00006450-198001000-00010. [DOI] [PubMed] [Google Scholar]
- Sólyom J., Hammond G. L., Vihko R. A method for identification and follow-up of patients with a steroid-21-hydroxylase deficiency. Clin Chim Acta. 1979 Mar 1;92(2):117–124. doi: 10.1016/0009-8981(79)90104-9. [DOI] [PubMed] [Google Scholar]
- Youssefnejadian E., David R. Early diagnosis of congenital adrenal hyperplasia by measurement of 17-hydroxyprogesterone. Clin Endocrinol (Oxf) 1975 Jul;4(4):451–454. doi: 10.1111/j.1365-2265.1975.tb01553.x. [DOI] [PubMed] [Google Scholar]