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. 1984 Nov;59(11):1034–1037. doi: 10.1136/adc.59.11.1034

Mycoplasma pneumoniae: acute illness, antibiotics, and subsequent pulmonary function.

A R Sabato, A J Martin, B P Marmion, T W Kok, D M Cooper
PMCID: PMC1628832  PMID: 6508338

Abstract

One hundred and eight children presenting with Mycoplasma pneumoniae infection were assessed during the acute illness and followed for three years. The incidence of wheezing with the acute infection (40%) was greater than expected in a normal childhood population. The initial illness precipitated wheezing for the first time in some subjects but others wheezed only with the acute illness. In non-asthmatic subjects significant bronchodilator responsiveness was present one month after infection. Children given erythromycin during the first seven days of their illness had a significantly shorter fever duration compared with those treated inappropriately. No significant effects of treatment were noted on pulmonary function three years later but non-asthmatic children had abnormal mean forced expiratory volume in one second and forced expiratory flow after 50% of the expired vital capacity compared with 64 healthy controls. These findings indicate impaired function three years after initial infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berkovich S., Millian S. J., Snyder R. D. The association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child. Ann Allergy. 1970 Feb;28(2):43–49. [PubMed] [Google Scholar]
  2. Dierckx J. P., Gillard C. The results of pulmonary function tests in patients infected with Mycoplasma pneumoniae. Infection. 1976;4(1 Suppl):68–70. doi: 10.1007/BF01638429. [DOI] [PubMed] [Google Scholar]
  3. Feizi T., Maclean H., Sommerville R. G., Selwyn J. G. Studies on an epidemic of respiratory disease caused by Mycoplasma pneumoniae. Br Med J. 1967 Feb 25;1(5538):457–460. doi: 10.1136/bmj.1.5538.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Henderson F. W., Clyde W. A., Jr, Collier A. M., Denny F. W., Senior R. J., Sheaffer C. I., Conley W. G., 3rd, Christian R. M. The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. J Pediatr. 1979 Aug;95(2):183–190. doi: 10.1016/s0022-3476(79)80647-2. [DOI] [PubMed] [Google Scholar]
  5. Jao R. L. Susceptibility of Mycoplasma pneumoniae to 21 antibiotics in vitro. Am J Med Sci. 1967 Jun;253(6):639–650. doi: 10.1097/00000441-196706000-00001. [DOI] [PubMed] [Google Scholar]
  6. KINGSTON J. R., CHANOCK R. M., MUFSON M. A., HELLMAN L. P., JAMES W. D., FOX H. H., MANKO M. A., BOYERS J. Eaton agent pneumonia. JAMA. 1961 Apr 15;176:118–123. doi: 10.1001/jama.1961.03040150034009. [DOI] [PubMed] [Google Scholar]
  7. Kjellman B. Pulmonary function in children with Mycoplasma pneumoniae pneumonia. Infection. 1976;4(1 Suppl):71–74. doi: 10.1007/BF01638430. [DOI] [PubMed] [Google Scholar]
  8. MARMION B. P., GOODBURN G. M. Effect of an organic gold salt on Eaton's primary atypical pneumonia agent and other observations. Nature. 1961 Jan 21;189:247–248. doi: 10.1038/189247a0. [DOI] [PubMed] [Google Scholar]
  9. Mok J. Y., Waugh P. R., Simpson H. Mycoplasma pneuminia infection. A follow-up study of 50 children with respiratory illness. Arch Dis Child. 1979 Jul;54(7):506–511. doi: 10.1136/adc.54.7.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rasch J. R., Mogabgab W. J. Therapeutic effect of erythromycin on Mycoplasma pneumoniae pneumonia. Antimicrob Agents Chemother (Bethesda) 1965;5:693–699. [PubMed] [Google Scholar]
  11. Sabato A. R., Cooper D. M., Thong Y. H. Transitory depression of immune function following Mycoplasma pneumoniae infection in children. Pediatr Res. 1981 May;15(5):813–816. [PubMed] [Google Scholar]
  12. Shames J. M., George R. B., Holliday W. B., Rasch J. R., Mogabgab W. J. Comparison of antibiotics in the treatment of mycoplasmal pneumonia. Arch Intern Med. 1970 Apr;125(4):680–684. [PubMed] [Google Scholar]
  13. Shames J. M., George R. B., Holliday W. B., Rasch J. R., Mogabgab W. J. Comparison of antibiotics in the treatment of mycoplasmal pneumonia. Arch Intern Med. 1970 Apr;125(4):680–684. [PubMed] [Google Scholar]
  14. Stadel B. V., Foy H. M., Nuckolls J. W., Kenny G. E. Mycoplasma pneumoniae infection followed by Haemophilus influenzae pneumonia and bacteremia. Am Rev Respir Dis. 1975 Jul;112(1):131–133. doi: 10.1164/arrd.1975.112.1.131. [DOI] [PubMed] [Google Scholar]
  15. Stevens D., Swift P. G., Johnston P. G., Kearney P. J., Corner B. D., Burman D. Mycoplasma pneumoniae infections in children. Arch Dis Child. 1978 Jan;53(1):38–42. doi: 10.1136/adc.53.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Williams H., McNicol K. N. Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children. An epidemiological study. Br Med J. 1969 Nov 8;4(5679):321–325. doi: 10.1136/bmj.4.5679.321. [DOI] [PMC free article] [PubMed] [Google Scholar]

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