Abstract
Seventy-nine patients with chronic bronchitis were randomly allotted to four treatment regimens—placebo throughout the winter months for five years; tetracycline for the first two winters and placebo for the next three; placebo for the first two winters and tetracycline for the next three; and tetracycline for five winters. In addition all groups recevied a five-day course of tetracycline for any acute exacerbation. There was a significant reduction in the number of exacerbations among the more susceptible patients—that is, those who suffered more than one exacerbation each winter. Though the average decline in F.E.V.1 over the five-year period was less in the treated groups this was not statistically significant. There was no significant difference between the groups in respect of lung volumes, diffusing capacity, and blood gases.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLAKEMORE W. S., FORSTER R. E., MORTON J. W., OGILVIE C. M. A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest. 1957 Jan;36(1 Pt 1):1–17. doi: 10.1172/JCI103402. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CAMPBELL E. J., HOWELL J. B. Simple rapid methods of estimating arterial and mixed venous pCO2. Br Med J. 1960 Feb 13;1(5171):458–462. doi: 10.1136/bmj.1.5171.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Calder M. A., Lutz W., Schonell M. E. A five year study of bacteriology and prophylactic chemotherapy in patients with chronic bronchitis. Br J Dis Chest. 1968 Apr;62(2):93–99. doi: 10.1016/s0007-0971(68)80040-3. [DOI] [PubMed] [Google Scholar]
- Jones N. L., Burrows B., Fletcher C. M. Serial studies of 100 patients with chronic airway obstruction in London and Chicago. Thorax. 1967 Jul;22(4):327–335. doi: 10.1136/thx.22.4.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malone D. N., Gold J. C., Grant I. W. A comparative study of ampicillin, tetracycline hydrochloride, and methacycline hydrochloride in acute exacerbations of chronic bronchitis. Lancet. 1968 Sep 14;2(7568):594–596. doi: 10.1016/s0140-6736(68)90695-8. [DOI] [PubMed] [Google Scholar]
- NEEDHAM C. D., ROGAN M. C., McDONALD I. Normal standards for lung volumes, intrapulmonary gas-mixing, and maximum breathing capacity. Thorax. 1954 Dec;9(4):313–325. doi: 10.1136/thx.9.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHWARTZ M. J., MIRSKY S., SCHAEFER L. E. PHENFORMIN, SERUM LIPIDS AND DIABETES MELLITUS. Lancet. 1965 May 1;1(7392):959–959. doi: 10.1016/s0140-6736(65)91286-9. [DOI] [PubMed] [Google Scholar]
- Wade O. L., Elmes P. C., Bartley E. Pathogenic organisms in the sputum of patients with chronic bronchitis. Thorax. 1967 May;22(3):265–270. doi: 10.1136/thx.22.3.265. [DOI] [PMC free article] [PubMed] [Google Scholar]