Abstract
Active non-specific immunotherapy has been used to prolong remissions in acute lymphoblastic leukaemia. The series reported here used Bordetella pertussis vaccine in a controlle trial after intensive chemotherapy. Possibly immunotherapy delayed the onset of relapse in the treated patients, but no long-term remissions were obtained. Further work is needed to establish the role of immunotherapy in general, and the use of B. pertussis vaccine in particular, in the treatment of acute leukaemia.
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Selected References
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- BIOZZI G., STIFFEL C., HALPERN B. N., MOUTON D. [Effect of inoculation with Calmette-Guerin bacillus on the development of Ehrlich ascites tumor in the mouse]. C R Seances Soc Biol Fil. 1959;153:987–989. [PubMed] [Google Scholar]
- Clausen C., Munoz J., Bergman R. K. Lymphocytosis and histamine sensitization of mice by fractions from Bordetella pertussis. J Bacteriol. 1968 Nov;96(5):1484–1487. doi: 10.1128/jb.96.5.1484-1487.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Finger H., Emmerling P., Schmidt H. Accelerated and prolongated multiplication of antibody-forming spleen cells by Bordetella pertussis in mice immunized with sheep red blood cells. Experientia. 1967 Jul 15;23(7):591–592. doi: 10.1007/BF02137991. [DOI] [PubMed] [Google Scholar]
- Floersheim G. L. Facilitation of tumour growth by Bacillus pertussis. Nature. 1967 Dec 23;216(5121):1235–1236. doi: 10.1038/2161235a0. [DOI] [PubMed] [Google Scholar]
- Mathé G., Amiel J. L., Schwarzenberg L., Schneider M., Cattan A., Schlumberger J. R., Hayat M., De Vassal F. Active immunotherapy for acute lymphoblastic leukaemia. Lancet. 1969 Apr 5;1(7597):697–699. doi: 10.1016/s0140-6736(69)92648-8. [DOI] [PubMed] [Google Scholar]
- OLD L. J., CLARKE D. A., BENACERRAF B. Effect of Bacillus Calmette-Guerin infection on transplanted tumours in the mouse. Nature. 1959 Jul 25;184(Suppl 5):291–292. doi: 10.1038/184291a0. [DOI] [PubMed] [Google Scholar]
- Woodruff M. F., Boak J. L. Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer. 1966 Jun;20(2):345–355. doi: 10.1038/bjc.1966.42. [DOI] [PMC free article] [PubMed] [Google Scholar]