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. 1977 Jul 2;2(6078):18–20. doi: 10.1136/bmj.2.6078.18

Mood changes in puerperium, and plasma tryptophan and cortisol concentrations.

S L Handley, T L Dunn, J M Baker, C Cockshott, S Gould
PMCID: PMC1631316  PMID: 559524

Abstract

Eighteen women aged 18-31 years were studied daily during the second to fifth postpartum days to assess mood changes and plasma tryptophan and cortisol concentrations. Psychiatric rating scales, clinical interviews, and published biochemical methods were used. Over the period plasma free tryptophan concentrations tended to rise and plasma cortisol concentrations to decline. There was a positive correlation between plasma free tryptophan concentrations and mood state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aylward M., Maddock J. Plasma-tryptophan levels in depression. Lancet. 1973 Apr 28;1(7809):936–936. doi: 10.1016/s0140-6736(73)91389-5. [DOI] [PubMed] [Google Scholar]
  2. BOARD F., PERSKY H., HAMBURG D. A. Psychological stress and endocrine functions; blood levels of adrenocortical and thyroid hormones in acutely disturbed patients. Psychosom Med. 1956 Jul-Aug;18(4):324–333. doi: 10.1097/00006842-195607000-00006. [DOI] [PubMed] [Google Scholar]
  3. Bender D. A., Boulton A. P., Coulson W. F. A simple method for the study of tryptophan binding to serum albumin by small-scale equilibrium dialysis: application to animal and human studies. Biochem Soc Trans. 1975;3(1):193–194. doi: 10.1042/bst0030193. [DOI] [PubMed] [Google Scholar]
  4. Bloxam D. L., Warren W. H. Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure. Anal Biochem. 1974 Aug;60(2):621–625. doi: 10.1016/0003-2697(74)90275-9. [DOI] [PubMed] [Google Scholar]
  5. Coppen A., Eccleston E. G., Peet M. Total and free tryptophan concentration in the plasma of depressive patients. Lancet. 1972 Dec 30;2(7792):1415–1416. doi: 10.1016/s0140-6736(72)92980-7. [DOI] [PubMed] [Google Scholar]
  6. Denckla W. D., Dewey H. K. The determination of tryptophan in plasma, liver, and urine. J Lab Clin Med. 1967 Jan;69(1):160–169. [PubMed] [Google Scholar]
  7. Hullin R. P., Bailey A. D., McDonald R., Dransfield G. A., Milne H. B. Variations in II-hydroxycorticosteroids in depression and manic-depressive psychosis. Br J Psychiatry. 1967 Jun;113(499):593–600. doi: 10.1192/bjp.113.499.593. [DOI] [PubMed] [Google Scholar]
  8. Knott P. J., Curzon G. Free tryptophan in plasma and brain tryptophan metabolism. Nature. 1972 Oct 20;239(5373):452–453. doi: 10.1038/239452a0. [DOI] [PubMed] [Google Scholar]
  9. Lapin I. P., Oxenkrug G. F. Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet. 1969 Jan 18;1(7586):132–136. doi: 10.1016/s0140-6736(69)91140-4. [DOI] [PubMed] [Google Scholar]
  10. MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. METCALFE M., GOLDMAN E. VALIDATION OF AN INVENTORY FOR MEASURING DEPRESSION. Br J Psychiatry. 1965 Mar;111:240–242. doi: 10.1192/bjp.111.472.240. [DOI] [PubMed] [Google Scholar]
  12. MIGEON C. J., PRYSTOWSKY H., GRUMBACH M. M., BYRON M. C. Placental passage of 17-hydroxycorticosteroids: comparison of the levels in maternal and fetal plasma and effect of ACTH and hydrocortisone administration. J Clin Invest. 1956 May;35(5):488–493. doi: 10.1172/JCI103301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Neckers L., Sze P. Y. Regulation of 5-hydroxytryptamine metabolism in mouse brain by adrenal glucocorticoids. Brain Res. 1975 Jul 25;93(1):123–132. doi: 10.1016/0006-8993(75)90290-5. [DOI] [PubMed] [Google Scholar]
  14. Niskanen P., Huttunen M., Tamminen T., Jäskeläinen J. The daily rhythm of plasma tryptophan and tyrosine in depression. Br J Psychiatry. 1976 Jan;128:67–73. doi: 10.1192/bjp.128.1.67. [DOI] [PubMed] [Google Scholar]
  15. Sachar E. J., Hellman L., Roffwarg H. P., Halpern F. S., Fukushima D. K., Gallagher T. F. Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Arch Gen Psychiatry. 1973 Jan;28(1):19–24. doi: 10.1001/archpsyc.1973.01750310011002. [DOI] [PubMed] [Google Scholar]
  16. van Praag H. M., Korf J. Central monoamine deficiency in depressions: causative of secondary phenomenon? Pharmakopsychiatr Neuropsychopharmakol. 1975 Sep;8(5):322–326. doi: 10.1055/s-0028-1094463. [DOI] [PubMed] [Google Scholar]

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