Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1977 Oct 22;2(6094):1047–1051. doi: 10.1136/bmj.2.6094.1047

Treatment of hepatic hydatid disease with mebedazole: preliminary results in four cases.

A Bekhti, J P Schaaps, M Capron, J P Dessaint, F Santoro, A Capron
PMCID: PMC1631834  PMID: 922416

Abstract

Mebendazole was given to four patients with hepatic hydatid disease. In three patients hydatidosis had remained after surgery, and in the fourth it could not be treated surgically. Mebendazole was given orally in maximum doses of 400-600 mg three times a day during courses lasting 21 to 30 days. Ultrasonic echotomography showed a complete regression of the intrahepatic cysts after four to 13 months in all four cases. In three patients the course of treatment had to be repeated. Mebendazole also induced clinical improvement and a progressive lowering of the concentration of specific IgE of Echinococcus granulosus. During treatment circulating blood levels of specific immune complexes of antigen 5 were increased. These observations indicate that mebendazole has a lethal effect on E granulosus cysts in primary hydatid disease in man and that the efficacy of chemotherapy can be assessed with ultrasonography and by measuring changes in the concentration of specific IgE of E granulosus and circulating immune complexes.

Full text

PDF
1049

Images in this article

1048FIG 1
on p.1048
1049FIG 2
on p.1049

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borgers M., De Nollin S., De Brabander M., Thienpont D. Influence of the anthelmintic mebendazole on microtubules and intracellular organelle movement in nematode intestinal cells. Am J Vet Res. 1975 Aug;36(08):1153–1166. [PubMed] [Google Scholar]
  2. Borgers M., De Nollin S. Ultrastructural changes in Ascaris suum intestine after mebendazole treatment in vivo. J Parasitol. 1975 Feb;61(1):110–122. [PubMed] [Google Scholar]
  3. Borgers M., De Nollin S., Verheyen A., Vanparijs O., Thienpont D. Morphological changes in cysticerci of Taenia taeniaeformis after mebendazole treatment. J Parasitol. 1975 Oct;61(5):830–843. [PubMed] [Google Scholar]
  4. Bout D., Santoro F., Carlier Y., Bina J. C., Capron A. Circulating immune complexes in schistosomiasis. Immunology. 1977 Jul;33(1):17–22. [PMC free article] [PubMed] [Google Scholar]
  5. Dessaint J. P., Bout D., Wattre P., Capron A. Quantitative determination of specific IgE antibodies to Echinococcus granulosus and IgE levels in sera from patients with hydatid disease. Immunology. 1975 Nov;29(5):813–823. [PMC free article] [PubMed] [Google Scholar]
  6. FISCHMAN A. REACTIVITY OF LATEX AND COMPLEMENT FIXATION TESTS IN HYDATID DISEASE. J Parasitol. 1965 Aug;51:497–500. [PubMed] [Google Scholar]
  7. GRABAR P., WILLIAMS C. A. Méthode permettant l'étude conjuguée des proprietés électrophorétiques et immunochimiques d'un mélange de protéines; application au sérum sanguin. Biochim Biophys Acta. 1953 Jan;10(1):193–194. doi: 10.1016/0006-3002(53)90233-9. [DOI] [PubMed] [Google Scholar]
  8. Kammerer W. S., Judge D. M. Chemotherapy of hydatid disease (Echinococcus granulosus) in mice with mebendazole and bithionol. Am J Trop Med Hyg. 1976 Sep;25(5):714–717. doi: 10.4269/ajtmh.1976.25.714. [DOI] [PubMed] [Google Scholar]
  9. PAUTRIZEL R., BAILENGER J. [Immunological diagnosis of echinococcosis]. Ann Biol Clin (Paris) 1961 Mar-Apr;19:243–252. [PubMed] [Google Scholar]
  10. Santoro F., Wattre P., Dessaint J. P., Capron A. Hepatitis B circulating immune complexes. Characterization by radioimmunoprecipitation--PEG assay (RIPEGA). J Immunol Methods. 1977;15(3):201–209. doi: 10.1016/0022-1759(77)90057-6. [DOI] [PubMed] [Google Scholar]
  11. Thienpont D. C., Vanparijs O. F., Hermans L. C. Mebendazole, a new potent drug against Syngamus trachea in turkeys. Poult Sci. 1973 Sep;52(5):1712–1714. doi: 10.3382/ps.0521712. [DOI] [PubMed] [Google Scholar]
  12. Thienpont D., Vanparijs O., Hermans L. Anthelmintic activity of mebendazole against Cysticercus fasciolaris. J Parasitol. 1974 Dec;60(6):1052–1053. [PubMed] [Google Scholar]
  13. Tsoufis E., Peveretos P. Résultats éloignés des opérations pour l'échinococcose du foie. Lyon Chir. 1969 Nov-Dec;65(6):865–872. [PubMed] [Google Scholar]
  14. Vanparijs O., Thienpont D. Anthelminthische Wirkung des Mebendazols gegen Nematoden und Zestoden bei Hunden. Dtsch Tierarztl Wochenschr. 1973 Jul 15;80(14):320–322. [PubMed] [Google Scholar]
  15. Yarzabal L., Dupas H., Bout D., Capron A. Echinococcus granulosus: distribution of hydatid fluid antigens in tissues of the larval stage. I. Localization of the specific antigen of hydatid fluid (antigen 5). Exp Parasitol. 1976 Dec;40(3):391–396. doi: 10.1016/0014-4894(76)90105-3. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES