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. 1977 Nov 5;2(6096):1179–1181. doi: 10.1136/bmj.2.6096.1179

Prolactin concentrations in ovulatory but infertile women: treatment with bromocriptine.

E A Lenton, O S Sobowale, I D Cooke
PMCID: PMC1632129  PMID: 589073

Abstract

We measured basal plasma prolactin concentrations (in samples obtained during the early follicular phase) in 25 normal (control) women and in a similar group of 40 patients with a long-standing history of infertility. The infertile patients were all ovulating regularly, and had been unsuccessfully treated with clomiphene and in some cases dydrogesterone and human menopausal gonadotrophin. Although none of the patients had plasma prolactin concentrations greater than 1000 muU/ml, 47.5% of the estimations were greater than 1 standard deviation (SD) above the mean established for our control group. This difference was highly significant (P less than 0.001). Treatment with various bromocriptine regimens effectively reduced prolactin concentrations to below normal in all cases, and 16 pregnancies followed-13 during bromocriptine treatment and three in the first post-treatment cycle. The cumulative conception rate was 63.4% after 10 months' treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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