Abstract
Eleven patients who had taken overdoses of barbiturates, glutethimide, tricyclic antidepressants, and chloroquine were treated by resin haemoperfusion using an R-004 haemoperfusion cartridge containing XAD-4 resin. All but one patient showed rapid clinical recovery and the drugs were cleared rapidly from the plasma. There were few complications. Resin haemoperfusion is more effective than dialysis and other perfusion methods, especially in poisoning with tricyclic antidepressants. Although haemoperfusion is expensive, it greatly reduces the length of the patient's stay in an intensive care unit and hence is cost-effective.
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- BROUGHTON P. M. A rapid ultraviolet spectrophotometric method for the detection, estimation and identification of barbiturates in biological material. Biochem J. 1956 Jun;63(2):207–213. doi: 10.1042/bj0630207. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hagstam K. E., Larsson L. E., Thysell H. Experimental studies on charcoal haemoperfusion in phenobarbital intoxication and uraemia, including histopathologic findings. Acta Med Scand. 1966 Nov;180(5):593–603. doi: 10.1111/j.0954-6820.1966.tb02875.x. [DOI] [PubMed] [Google Scholar]
- KISSACK A. S., Jr, GLIEDMAN M. L., KARLSON K. E. Studies with ion exchange resins. Trans Am Soc Artif Intern Organs. 1962;8:219–225. doi: 10.1097/00002480-196204000-00047. [DOI] [PubMed] [Google Scholar]
- Medd R. K., Widdop B., Braithwaite R. A., Rees A. J., Goulding R. Comparison of haemoperfusion and haemodialysis in the therapy of barbiturate intoxication in dogs. Arch Toxikol. 1973;31(2):163–174. doi: 10.1007/BF00310394. [DOI] [PubMed] [Google Scholar]
- Rosenbaum J. L., Kramer M. S., Raja R. Resin hemoperfusion for acute drug intoxication. Arch Intern Med. 1976 Mar;136(3):263–266. [PubMed] [Google Scholar]
- YATZIDIS H., OREOPOULOS D., TRIANTAPHYLLIDIS D., VOUDICLARI S., TSAPARAS N., GAVRAS C., STAVROULAKI A. TREATMENT OF SEVERE BARBITURATE POISONING. Lancet. 1965 Jul 31;2(7405):216–217. doi: 10.1016/s0140-6736(65)90698-7. [DOI] [PubMed] [Google Scholar]