Abstract
The results of two large independent studies involving a combined total of 776 patients treated in hospital with a discharge diagnosis of acute myocardial infarction and 13,898 patients with other discharge diagnoses showed a negative association between regular aspirin intake and non-fatal myocardial infarction. The data are consistent with the hypothesis that aspirin protects against this disease. Clinical trials are needed to determine whether this hypothesis is correct.
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Selected References
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- Elwood P. C., Cochrane A. L., Burr M. L., Sweetnam P. M., Williams G., Welsby E., Hughes S. J., Renton R. A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J. 1974 Mar 9;1(5905):436–440. doi: 10.1136/bmj.1.5905.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jick H., Miettinen O. S., Neff R. K., Shapiro S., Heinonen O. P., Slone D. Coffee and myocardial infarction. N Engl J Med. 1973 Jul 12;289(2):63–67. doi: 10.1056/NEJM197307122890203. [DOI] [PubMed] [Google Scholar]
- Jones B., Leeton J., McLeod I., Wood C. Factors influencing the age of menarche in a lower socio-economic group in Melbourne. Med J Aust. 1972 Sep 2;2(10):533–535. doi: 10.5694/j.1326-5377.1972.tb47460.x. [DOI] [PubMed] [Google Scholar]
- MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
- O'Brien J. R. Effects of salicylates on human platelets. Lancet. 1968 Apr 13;1(7546):779–783. doi: 10.1016/s0140-6736(68)92228-9. [DOI] [PubMed] [Google Scholar]
- Weiss H. J., Aledort L. M. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet. 1967 Sep 2;2(7514):495–497. doi: 10.1016/s0140-6736(67)91658-3. [DOI] [PubMed] [Google Scholar]
- Weiss H. J., Aledort L. M., Kochwa S. The effect of salicylates on the hemostatic properties of platelets in man. J Clin Invest. 1968 Sep;47(9):2169–2180. doi: 10.1172/JCI105903. [DOI] [PMC free article] [PubMed] [Google Scholar]