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. 1974 Mar 9;1(5905):421–424. doi: 10.1136/bmj.1.5905.421

Instability of Polymeric Skin Collagen in Osteogenesis Imperfecta

M J O Francis, Roger Smith, Robert J Bauze
PMCID: PMC1633248  PMID: 4816854

Abstract

The structural polymeric collagen of the skin of 19 patients with osteogenesis imperfecta has been examined. In those with severe bone disease, who often have white sclerae, this collagen fraction is less resistant to depolymerization than that of age-matched controls, though the total amount is normal. In patients with less severe bone disease, whose sclerae are usually blue, the polymeric collagen may have normal stability but the total amount is reduced. These results suggest defective cross-linking of collagen in severe osteogenesis imperfecta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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