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. 1997 Jan;41(1):193–195. doi: 10.1128/aac.41.1.193

Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.

T Mizushima 1, M Matsuo 1, K Sekimizu 1
PMCID: PMC163685  PMID: 8980780

Abstract

Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to those required for DNA relaxation and much higher than those required for cell death.

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Selected References

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