Abstract
A method is described for the assay of the behavioral effects of volatile solvents on mice and illustrated with pilot results on trichlorethylene. A dose-effect curve has been determined for the effects on schedule controlled responding and compared with the dose-lethality curve and the TLV for man. The OR50 for behavioral effects was 1/5 of the LD50 and 50 times the TLV for long-term exposure of man. An analysis of the errors involved in determination of effects on whole animals leads to the conclusion that subtle effects, representing a few per cent change, will not be detectable in routine screening. It is suggested nevertheless that information on the midrange, knowable, part of the dose-effect curve may prove useful in predicting safe levels for man.
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Selected References
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- Schneiderman M. A., Mantel N., Brown C. C. From mouse to man--or how to get from the laboratory to Park Avenue and 59th Street. Ann N Y Acad Sci. 1975 Jan 31;246:237–248. doi: 10.1111/j.1749-6632.1975.tb51098.x. [DOI] [PubMed] [Google Scholar]
- Wenger G. R., Dews P. B. The effects of phencyclidine, ketamine, delta-amphetamine and pentobarbital on schedule-controlled behavior in the mouse. J Pharmacol Exp Ther. 1976 Mar;196(3):616–624. [PubMed] [Google Scholar]