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. 2000 Feb;108(2):93–96. doi: 10.1289/ehp.0010893

The role of epidemiology in the detection of harmful effects of radiation.

A Stewart 1
PMCID: PMC1637879  PMID: 10656847

Abstract

Data relating to acute injuries of atomic bomb survivors show that the life span study cohort is biased in favor of exceptionally low levels of radiosensitivity. These data also show that factors influencing the death rates of this cohort include irreversible damage to the immune system. These impressions are still awaiting confirmation. Meanwhile, the Oxford Survey of Childhood Cancers and surveys of nuclear workers show that at low dose levels the cancer risk is much greater than estimates based on atomic bomb survivors; the special association between leukemia and radiation is an exclusively high dose effect, and levels of radiosensitivity are much lower in the middle of the life span than at either extreme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cardis E., Gilbert E. S., Carpenter L., Howe G., Kato I., Armstrong B. K., Beral V., Cowper G., Douglas A., Fix J. Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res. 1995 May;142(2):117–132. [PubMed] [Google Scholar]
  2. Doll R., Wakeford R. Risk of childhood cancer from fetal irradiation. Br J Radiol. 1997 Feb;70:130–139. doi: 10.1259/bjr.70.830.9135438. [DOI] [PubMed] [Google Scholar]
  3. Fagan D. G., Walker A. Haemoglobin F levels in sudden infant deaths. Br J Haematol. 1992 Oct;82(2):422–430. doi: 10.1111/j.1365-2141.1992.tb06440.x. [DOI] [PubMed] [Google Scholar]
  4. Gilbert E. S., Marks S. An analysis of the mortality of workers in a nuclear facility. Radiat Res. 1979 Jul;79(1):122–148. [PubMed] [Google Scholar]
  5. HEWITT D. Some features of leukaemia mortality. Br J Prev Soc Med. 1955 Apr;9(2):81–88. doi: 10.1136/jech.9.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JABLON S., ISHIDA M., YAMASAKI M. STUDIES OF THE MORTALITY OF A-BOMB SURVIVORS. 3. DESCRIPTION OF THE SAMPLE AND MORTALITY, 1950--1960. Radiat Res. 1965 May;25:25–52. [PubMed] [Google Scholar]
  7. Kneale G. W. Excess sensitivity of pre-leukaemics to pneumonia. A model situation for studying the interaction of infectious disease with cancer. Br J Prev Soc Med. 1971 Aug;25(3):152–159. doi: 10.1136/jech.25.3.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kneale G. W., Mancuso T. F., Stewart A. M. Hanford radiation study III: a cohort study of the cancer risks from radiation to workers at Hanford (1944-77 deaths) by the method of regression models in life-tables. Br J Ind Med. 1981 May;38(2):156–166. doi: 10.1136/oem.38.2.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kneale G. W., Stewart A. M. Age variation in the cancer risks from foetal irradiation. Br J Cancer. 1977 Oct;36(4):501–510. doi: 10.1038/bjc.1977.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kneale G. W., Stewart A. M. Mantel-Haenszel analysis of Oxford data. II. Independent effects of fetal irradiation subfactors. J Natl Cancer Inst. 1976 Nov;57(5):1009–1014. doi: 10.1093/jnci/57.5.1009. [DOI] [PubMed] [Google Scholar]
  11. Kneale G. W., Stewart A. M. Reanalysis of Hanford data: 1944-1986 deaths. Am J Ind Med. 1993 Mar;23(3):371–389. doi: 10.1002/ajim.4700230302. [DOI] [PubMed] [Google Scholar]
  12. Mancuso T. F., Stewart A., Kneale G. Radiation exposures of Hanford workers dying from cancer and other causes. Health Phys. 1977 Nov;33:369–385. doi: 10.1097/00004032-197711000-00002. [DOI] [PubMed] [Google Scholar]
  13. Neriishi K., Stram D. O., Vaeth M., Mizuno S., Akiba S. The observed relationship between the occurrence of acute radiation effects and leukemia mortality among A-bomb survivors. Radiat Res. 1991 Feb;125(2):206–213. [PubMed] [Google Scholar]
  14. Ritz B., Morgenstern H., Froines J., Young B. B. Effects of exposure to external ionizing radiation on cancer mortality in nuclear workers monitored for radiation at Rocketdyne/Atomics International. Am J Ind Med. 1999 Jan;35(1):21–31. doi: 10.1002/(sici)1097-0274(199901)35:1<21::aid-ajim4>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  15. STEWART A., WEBB J., HEWITT D. A survey of childhood malignancies. Br Med J. 1958 Jun 28;1(5086):1495–1508. doi: 10.1136/bmj.1.5086.1495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Shimizu Y., Kato H., Schull W. J., Hoel D. G. Studies of the mortality of A-bomb survivors. 9. Mortality, 1950-1985: Part 3. Noncancer mortality based on the revised doses (DS86). Radiat Res. 1992 May;130(2):249–266. [PubMed] [Google Scholar]
  17. Stewart A. M. Delayed effects of A-bomb radiation: a review of recent mortality rates and risk estimates for five-year survivors. J Epidemiol Community Health. 1982 Jun;36(2):80–86. doi: 10.1136/jech.36.2.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stewart A. M., Kneale G. W. A-bomb radiation and evidence of late effects other than cancer. Health Phys. 1990 Jun;58(6):729–735. doi: 10.1097/00004032-199006000-00004. [DOI] [PubMed] [Google Scholar]
  19. Stewart A. M., Kneale G. W. A-bomb survivors: further evidence of late effects of early deaths. Health Phys. 1993 May;64(5):467–472. doi: 10.1097/00004032-199305000-00002. [DOI] [PubMed] [Google Scholar]
  20. Stewart A. M., Kneale G. W. The immune system and cancers of foetal origin. Cancer Immunol Immunother. 1982;14(2):110–116. doi: 10.1007/BF00200178. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stewart A. M. Leukaemia and sudden death. Leuk Res. 1998 Mar;22(3):289–289. doi: 10.1016/s0145-2126(97)00167-7. [DOI] [PubMed] [Google Scholar]
  22. Stewart A. Childhood cancers and competing causes of death. Leuk Res. 1995 Feb;19(2):103–111. doi: 10.1016/0145-2126(94)00122-q. [DOI] [PubMed] [Google Scholar]
  23. Stewart A. Detecting the health risks of radiation. Med Confl Surviv. 1999 Apr-Jun;15(2):138–148. doi: 10.1080/13623699908409448. [DOI] [PubMed] [Google Scholar]
  24. Wing S., Shy C. M., Wood J. L., Wolf S., Cragle D. L., Frome E. L. Mortality among workers at Oak Ridge National Laboratory. Evidence of radiation effects in follow-up through 1984. JAMA. 1991 Mar 20;265(11):1397–1402. [PubMed] [Google Scholar]
  25. Yoshimoto Y., Kato H., Schull W. J. Risk of cancer among children exposed in utero to A-bomb radiations, 1950-84. Lancet. 1988 Sep 17;2(8612):665–669. doi: 10.1016/s0140-6736(88)90477-1. [DOI] [PubMed] [Google Scholar]

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