Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1976 Apr 10;1(6014):872–874. doi: 10.1136/bmj.1.6014.872

Therapeutic experience with fludrocortisone in diabetic postural hypotension.

I W Campbell, D J Ewing, B F Clarke
PMCID: PMC1639594  PMID: 769906

Abstract

Fourteen patients with diabetic postural hypotension were treated with fludrocortisone for a mean 12 months (range 6-30 months). The mean daily dose of fludrocortisone was 0.2 mg (range 0.1 mg-0.4 mg). Standing systolic and diastolic blood pressures increased significantly (P less than 0.001) after treatment with fludrocortisone and the postural hypotension decreased significantly (P less than 0.001). Thirteen patients noted considerable symptomatic improvement. Fludrocortisone should be used cautiously in patients with congestive cardiac failure or the nephrotic syndrome.

Full text

PDF
873

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bannister R., Ardill L., Fentem P. An assessment of various methods of treatment of idiopathic orthostatic hypotension. Q J Med. 1969 Oct;38(152):377–395. [PubMed] [Google Scholar]
  2. Bannister R. Degeneration of the autonomic nervous system. Lancet. 1971 Jul 24;2(7717):175–179. doi: 10.1016/s0140-6736(71)90893-2. [DOI] [PubMed] [Google Scholar]
  3. Campbell I. W., Ewing D. J., Clarke B. F. 9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. Diabetes. 1975 Apr;24(4):381–384. doi: 10.2337/diab.24.4.381. [DOI] [PubMed] [Google Scholar]
  4. Christlieb A. R., Munichoodappa C., Braaten J. T. Decreased response of plasma renin activity to orthostasis in diabetic patients with orthostatic hypotension. Diabetes. 1974 Oct;23(10):835–840. doi: 10.2337/diab.23.10.835. [DOI] [PubMed] [Google Scholar]
  5. Ewing D. J., Campbell I. W., Burt A. A., Clarke B. F. Vascular reflexes in diabetic autonomic neuropathy. Lancet. 1973 Dec 15;2(7842):1354–1356. doi: 10.1016/s0140-6736(73)93323-0. [DOI] [PubMed] [Google Scholar]
  6. Finch P. J. Extensive autonomic neuropathy in diabetes. Proc R Soc Med. 1971 Aug;64(8):803–804. [PMC free article] [PubMed] [Google Scholar]
  7. HICKLER R. B., THOMPSON G. R., FOX L. M., HAMLIN J. T., 3rd Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone. N Engl J Med. 1959 Oct 15;261:788–791. doi: 10.1056/NEJM195910152611604. [DOI] [PubMed] [Google Scholar]
  8. SCHATZ I. J., PODOLSKY S., FRAME B. IDIOPATHIC ORTHOSTATIC HYPOTENSION. DIAGNOSIS AND TREATMENT. JAMA. 1963 Nov 9;186:537–540. doi: 10.1001/jama.1963.03710060023005. [DOI] [PubMed] [Google Scholar]
  9. Schmid P. G., Eckstein J. W., Abboud F. M. Effect of 9-alpha-fluorohydrocortisone on forearm vascular responses to norepinephrine. Circulation. 1966 Oct;34(4):620–626. doi: 10.1161/01.cir.34.4.620. [DOI] [PubMed] [Google Scholar]
  10. Shear L. Orthostatic hypotension. Treatment with sodium chloride and sodium retaining steroid hormones. Arch Intern Med. 1968 Dec;122(6):467–471. doi: 10.1001/archinte.122.6.467. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES