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. 1976 May 22;1(6020):1247–1250. doi: 10.1136/bmj.1.6020.1247

Evidence for familial immune defect in meningococcal meningitis.

H C Whittle, A Oduloju, G Evans-Jones, B M Greenwood
PMCID: PMC1639823  PMID: 817771

Abstract

Twenty-six patients who had recovered from group A meningococcal meningitis were vaccinated with group C meningococcal polysaccharide and tetanus toxoid. Their haemagglutinating antibody response was measured two weeks later and compared with those of 22 siblings and 39 controls. Patients and siblings had a significantly lower antibody response to the group C vaccine but not to tetanus toxoid. This suggests that patients susceptible to meningococcal disease may have an immune defect involving their response to meningococcal polysaccharides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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