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American Journal of Public Health logoLink to American Journal of Public Health
. 1986 Aug;76(8):986–991. doi: 10.2105/ajph.76.8.986

Characteristics of women with recurrent spontaneous abortions and women with favorable reproductive histories.

B Strobino, H E Fox, J Kline, Z Stein, M Susser, D Warburton
PMCID: PMC1646627  PMID: 3728772

Abstract

Women with a history of recurrent spontaneous abortions (repeaters) are compared with women who have had live births and no spontaneous abortions (multiparae) and women who have had live births and only one spontaneous abortion (sporadics) to identify characteristics of the women and their abortuses that might predict subsequent fetal loss. A number of risk factors for recurrent spontaneous abortion have been identified: the loss of a chromosomally normal conception, loss after the first trimester of pregnancy, a delay in conceiving prior to the study pregnancy, a diagnosis of cervical incompetence, and a history of very low birthweight deliveries. The odds ratios associated with being a repeater vary from 1.4 to 5.6 depending on the number of characteristics present.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boué J., Bou A, Lazar P. Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology. 1975 Aug;12(1):11–26. doi: 10.1002/tera.1420120103. [DOI] [PubMed] [Google Scholar]
  2. Byrd J. R., Askew D. E., McDonough P. G. Cytogenetic findings in fifty-five couples with recurrent fetal wastage. Fertil Steril. 1977 Mar;28(3):246–250. doi: 10.1016/s0015-0282(16)42433-7. [DOI] [PubMed] [Google Scholar]
  3. Horta J. L., Fernández J. G., de León B. S., Cortés-Gallegos V. Direct evidence of luteal insufficiency in women with habitual abortion. Obstet Gynecol. 1977 Jun;49(6):705–708. [PubMed] [Google Scholar]
  4. JAMES W. H. On the possibility of segregation in the propensity to spontaneous abortion in the human female. Ann Hum Genet. 1961 Dec;25:207–213. doi: 10.1111/j.1469-1809.1962.tb01521.x. [DOI] [PubMed] [Google Scholar]
  5. Kline J., Shrout P., Stein Z., Susser M., Warburton D. Drinking during pregnancy and spontaneous abortion. Lancet. 1980 Jul 26;2(8187):176–180. doi: 10.1016/s0140-6736(80)90062-8. [DOI] [PubMed] [Google Scholar]
  6. Kline J., Stein Z. A., Susser M., Warburton D. Smoking: a risk factor for spontaneous abortion. N Engl J Med. 1977 Oct 13;297(15):793–796. doi: 10.1056/NEJM197710132971501. [DOI] [PubMed] [Google Scholar]
  7. Komlos L., Zamir R., Joshua H., Halbrecht I. Common HLA antigens in couples with repeated abortions. Clin Immunol Immunopathol. 1977 May;7(3):330–335. doi: 10.1016/0090-1229(77)90066-6. [DOI] [PubMed] [Google Scholar]
  8. Lauritsen J. G. Aetiology of spontaneous abortion. A cytogenetic and epidemiological study of 288 abortuses and their parents. Acta Obstet Gynecol Scand Suppl. 1976;52:1–29. [PubMed] [Google Scholar]
  9. ROWLEY P. T., MARSHALL R., ELLIS J. R. A GENETICAL AND CYTOLOGICAL STUDY OF REPEATED SPONTANEOUS ABORTION. Ann Hum Genet. 1963 Aug;27:87–100. doi: 10.1111/j.1469-1809.1963.tb00784.x. [DOI] [PubMed] [Google Scholar]
  10. Rocklin R. E., Kitzmiller J. L., Carpenter C. B., Garovoy M. R., David J. R. Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions. N Engl J Med. 1976 Nov 25;295(22):1209–1213. doi: 10.1056/NEJM197611252952201. [DOI] [PubMed] [Google Scholar]
  11. Schwartz S., Palmer C. G. Chromosomal findings in 164 couples with repeated spontaneous abortions: with special consideration to prior reproductive history. Hum Genet. 1983;63(1):28–34. doi: 10.1007/BF00285393. [DOI] [PubMed] [Google Scholar]
  12. WARBURTON D., FRASER F. C. On the probability that a woman who has had a spontaneous abortion will abort in subsequent pregnancies. J Obstet Gynaecol Br Emp. 1961 Oct;68:784–788. doi: 10.1111/j.1471-0528.1961.tb02810.x. [DOI] [PubMed] [Google Scholar]
  13. Yip S. K., Sung M. L. Plasma progesterone in women with a history of recurrent early abortions. Fertil Steril. 1977 Feb;28(2):151–155. doi: 10.1016/s0015-0282(16)42373-3. [DOI] [PubMed] [Google Scholar]

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