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. 1986 Jul;76(7):783–786. doi: 10.2105/ajph.76.7.783

A case-control study to evaluate the effectiveness of mass neonatal BCG vaccination among Canadian Indians.

T K Young, E S Hershfield
PMCID: PMC1646870  PMID: 3717464

Abstract

This paper reports a case-control study to assess the protective effect of BCG (bacille Calmette-Guérin) vaccination among Indian infants in Manitoba, Canada. A record of past BCG vaccination was found in 49 per cent of the tuberculosis cases, compared to 77 per cent of the controls, yielding a relative risk of 0.30. Stratified analysis, controlling for age, increased the relative risk to 0.39 (95% confidence interval 0.22 - 0.69). The preventive fraction was 44 per cent. Non-differential misclassification of exposure status could have occurred; if this was adjusted for, the relative risk would be reduced. If only bacteriologically confirmed cases were analyzed, the age-adjusted relative risk was 0.27. The protective effect of BCG vaccination in the newborn among Manitoba Indians is therefore at least 60 per cent. The implications for health policy in this population are further discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BCG vaccination in the newborn. Br Med J. 1980 Nov 29;281(6253):1445–1446. [PMC free article] [PubMed] [Google Scholar]
  2. Clemens J. D., Chuong J. J., Feinstein A. R. The BCG controversy. A methodological and statistical reappraisal. JAMA. 1983 May 6;249(17):2362–2369. [PubMed] [Google Scholar]
  3. Curtis H. M., Leck I., Bamford F. N. Incidence of childhood tuberculosis after neonatal BCG vaccination. Lancet. 1984 Jan 21;1(8369):145–148. doi: 10.1016/s0140-6736(84)90072-2. [DOI] [PubMed] [Google Scholar]
  4. Dam H. G., Toman K., Hitze K. L., Guld J. Present knowledge of immunization against tuberculosis. Bull World Health Organ. 1976;54(3):255–269. [PMC free article] [PubMed] [Google Scholar]
  5. Eickhoff T. C. The current status of BCG immunization against tuberculosis. Annu Rev Med. 1977;28:411–423. doi: 10.1146/annurev.me.28.020177.002211. [DOI] [PubMed] [Google Scholar]
  6. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  7. Miettinen O. S. Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol. 1974 May;99(5):325–332. doi: 10.1093/oxfordjournals.aje.a121617. [DOI] [PubMed] [Google Scholar]
  8. Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
  9. Narain R. Need for a BCG trial in Canada's native populations. Can Med Assoc J. 1982 Jul 15;127(2):101–102. [PMC free article] [PubMed] [Google Scholar]
  10. Smith P. G. Retrospective assessment of the effectiveness of BCG vaccination against tuberculosis using the case-control method. Tubercle. 1982 Mar;63(1):23–35. doi: 10.1016/s0041-3879(82)80006-8. [DOI] [PubMed] [Google Scholar]
  11. Styblo K. Recent advances in epidemiological research in tuberculosis. Adv Tuberc Res. 1980;20:1–63. [PubMed] [Google Scholar]
  12. Sutherland I. Recent studies in the epidemiology of tuberculosis, based on the risk of being infected with tubercle bacilli. Adv Tuberc Res. 1976;19:1–63. [PubMed] [Google Scholar]
  13. Young T. K. BCG vaccination among Canadian Indians and Inuit: the epidemiological bases for policy decision. Can J Public Health. 1985 Mar-Apr;76(2):124–129. [PubMed] [Google Scholar]
  14. ten Dam H. G., Hitze K. L. Does BCG vaccination protect the newborn and young infants? Bull World Health Organ. 1980;58(1):37–41. [PMC free article] [PubMed] [Google Scholar]

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