Abstract
The effect of breast milk and 3α, 20β-pregnanediol on the conjugation of bilirubin and o-aminophenol by rat liver was compared. Breast milk inhibited glucuronyl transferase, whereas 3α, 20β-pregnanediol inhibited the secretion of bilirubin glucuronide from rat liver slices. In the inhibitory breast milk examined the steroid was probably not the sole inhibitory factor.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ARIAS I. M., GARTNER L. M. PRODUCTION OF UNCONJUGATED HYPERBILIRUBINAEMIA IN FULL-TERM NEW-BORN INFANTS FOLLOWING ADMINISTRATION OF PREGNANE-3(ALPHA),20(BETA)-DIOL. Nature. 1964 Sep 19;203:1292–1293. doi: 10.1038/2031292b0. [DOI] [PubMed] [Google Scholar]
- ARIAS I. M., GARTNER L. M., SEIFTER S., FURMAN M. PROLONGED NEONATAL UNCONJUGATED HYPERBILIRUBINEMIA ASSOCIATED WITH BREAST FEEDING AND A STEROID, PREGNANE-3(ALPHA), 20(BETA)-DIOL, IN MATERNAL MILK THAT INHIBITS GLUCURONIDE FORMATION IN VITRO. J Clin Invest. 1964 Nov;43:2037–2047. doi: 10.1172/JCI105078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Adlard B. P., Lathe G. H. Breast milk jaundice: effect of 3-alpha 20-beta-pregnanediol on bilirubin conjugation by human liver. Arch Dis Child. 1970 Apr;45(240):186–189. doi: 10.1136/adc.45.240.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BILLING B. H., MAGGIORE Q., CARTTER M. A. HEPATIC TRANSPORT OF BILIRUBIN. Ann N Y Acad Sci. 1963 Dec 30;111:319–325. doi: 10.1111/j.1749-6632.1963.tb36974.x. [DOI] [PubMed] [Google Scholar]
- Bevan B. R., Holton J. B., Lathe G. H. The effect of pregnanediol and pregnanediol glucuronide on bilirubin conjugation by rat liver slices. Clin Sci. 1965 Oct;29(2):353–361. [PubMed] [Google Scholar]
- HARGREAVES T. THE ESTIMATION OF BILIRUBIN IN LIVER. Clin Chim Acta. 1965 Mar;11:278–280. doi: 10.1016/0009-8981(65)90075-6. [DOI] [PubMed] [Google Scholar]
- LATHE G. H., WALKER M. Inhibition of bilirubin conjugation in rat liver slices by human pregnancy and neonatal serum and steroids. Q J Exp Physiol Cogn Med Sci. 1958 Jul;43(3):257–265. doi: 10.1113/expphysiol.1958.sp001328. [DOI] [PubMed] [Google Scholar]
- LATHE G. H., WALKER M. The synthesis of bilirubin glucuronide in animal and human liver. Biochem J. 1958 Dec;70(4):705–712. doi: 10.1042/bj0700705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levvy G. A., Storey I. D. The measurement of glucuronide synthesis by tissue preparations. Biochem J. 1949;44(3):295–299. doi: 10.1042/bj0440295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEVENSON I. H., DUTTON G. J. Glucuronide synthesis in kidney and gastrointestinal tract. Biochem J. 1962 Feb;82:330–340. doi: 10.1042/bj0820330. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Roy F. P., Heirwegh K. P. Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor. Biochem J. 1968 Apr;107(4):507–518. doi: 10.1042/bj1070507. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEINBREN K., BILLING B. H. Hepatic clearance of bilirubin as an index of cellular function in the regenerating rat liver. Br J Exp Pathol. 1956 Apr;37(2):199–204. [PMC free article] [PubMed] [Google Scholar]