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. 1970 Aug;45(242):485–490. doi: 10.1136/adc.45.242.485

A Disorder of Tryptophan Metabolism in Chronic Granulomatous Disease

A F Heeley, Mary E Heeley, Jennifer Hardy, J F Soothill
PMCID: PMC1647666  PMID: 4248383

Abstract

5 children with chronic granulomatous disease had a disorder of tryptophan metabolism, resulting in excretion of gross excess of hydroxykynurenine, kynurenine, and xanthurenic acid, with or without tryptophan loading. Hydroxykynurenine predominated, and in this and other ways the findings were different from those present in most defects of tryptophan metabolism, but were similar to those in pyridoxine deficiency. Oral pyridoxine 30 mg./day corrected this defect, but had no effect on the nitroblue tetrazolium reaction, or bacterial killing by polymorphonuclear leucocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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